[Study on molecular epidemiology of HCMV infection in mothers and their newborns in Changsha].
[Study on molecular epidemiology of HCMV infection in mothers and their newborns in Changsha].
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发表时间：
2001-02
期刊：
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通讯作者：
G. Wu;S. Chen;L. Y. Chen
中科院分区：
文献类型：
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作者：
G. Wu;S. Chen;L. Y. Chen
ELISA法检测血浆HCMV-IgG、IgM， PCR法检测母亲及其新生儿血浆DNA和P(C) BMCs。125例产妇中HCMV- igg、HCMV- igm、P(C)BMCs HCMV DNA和血浆HCMV DNA阳性分别为119例（95.2%）、7例（5.6%）、27例（21.6%）和14例（11.2%），新生儿分别为117例（93.6%）、1例（0.8%）、18例（14.4%）和7例（5.6%）。新生儿HCMV- igm阳性率、血浆HCMV DNA阳性率、新生儿新生儿HCMV DNA阳性率差异有统计学意义（P < 0.05）。本研究提示HCMV- igg和CBMCs HCMV PCR分别是孕妇和新生儿HCMV感染较好的流行病学指标。
The detection of HCMV-IgG, IgM in plasma by ELISA and DNA in plasma and P(C) BMCs from mothers and their newborns by PCR was carried out. Positive HCMV-IgG, HCMV-IgM, P(C)BMCs HCMV DNA and plasma HCMV DNA were demonstrated in 119(95.2%), 7(5.6%), 27(21.6%) and 14(11.2%) in 125 mothers and 117(93.6%), 1(0.8%), 18(14.4%) and 7(5.6%) in their mewborns, respectively. There were significant differences among the positive rate of newborn's HCMV-IgM, plasma HCMV DNA and CBMCs HCMV DNA (P 0.05). This study suggests that HCMV-IgG and CBMCs HCMV PCR are preferable epidemiological index of HCMV infection of pregnant women and newborns respectively.