CHRONIC INTERSTITIAL CYSTITIS - A HETEROGENEOUS SYNDROME
CHRONIC INTERSTITIAL CYSTITIS - A HETEROGENEOUS SYNDROME
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DOI：
10.1016/s0022-5347(17)43863-8
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发表时间：
1987-01-01
影响因子：
6.6
通讯作者：
ALDENBORG, F
中科院分区：
文献类型：
--
作者：
FALL, M;JOHANSSON, SL;ALDENBORG, F
对28例间质性膀胱炎患者和14例健康志愿者进行了研究。我们发现经典（溃疡性）间质性膀胱炎和早期（非溃疡性）间质性膀胱炎之间有显著的组织病理学差异。经典型患者膀胱粘膜局灶性溃疡、水肿及神经血管周围浸润。有2个不同的肥大细胞群显着增加。逼尿肌和逼尿肌粘膜肥大细胞增多。与肌被中的肥大细胞不同，粘液性肥大细胞对醛固定敏感，需要特殊的固定和染色技术才能正确显示。这些细胞在上皮中数量众多，并在膀胱冲洗液中回收，这与它们具有迁移能力的发现一致。在非溃疡性间质性膀胱炎中，肥大细胞活化的所有迹象均不存在，组织病理学变化很少且相当不典型。我们还观察到溃疡性和非溃疡性间质性膀胱炎之间的一些显著临床差异。这2种疾病似乎代表不同的实体，应在临床研究中单独评价。
A series of 28 patients with interstitial cystitis and 14 healthy volunteers were studied. We found marked histopathological differences between classic (ulcerative) interstitial cystitis and early (nonulcerative) interstitial cystitis. The bladder mucosa of patients with classic disease exhibited focal ulceration, edema and perineural-perivascular infiltrates. There was a marked increase in 2 distinct mast cell populations. Mast cells increased in the detrusor muscle and mucosa. Mucosal mast cells, unlike those in the muscular coat, are susceptible to aldehyde fixation, and require special fixation and staining techniques for proper demonstration. These cells were numerous in the epithelium and were recovered in bladder washings, consistent with the finding that they have a migratory capacity. In nonulcerative interstitial cystitis all signs of mast cell activation were absent, and the histopathological changes were few and fairly uncharacteristic. We also observed some marked clinical differences between ulcerative and nonulcerative interstitial cystitis. These 2 conditions appear to represent separate entities and should be evaluated separately in clinical studies.