RNA BioMolecular Electronics: towards new tools for biophysics and biomedicine
RNA BioMolecular Electronics: towards new tools for biophysics and biomedicine
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DOI：
10.1039/d1tb01141c
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发表时间：
2021-09-08
影响因子：
7
通讯作者：
Artes Vivancos, Juan M.
中科院分区：
文献类型：
--
作者：
Pattiya Arachchillage, Keshani G. Gunasinghe;Chandra, Subrata;Artes Vivancos, Juan M.
在过去的半个世纪里，一个新的多学科领域的诞生和发展在材料科学，纳米科学，工程和化学之间的边缘，被称为分子电子学。该领域涉及单个分子的电子特性及其作为电子电路中的有源元件的集成，并且也已应用于生物分子，导致生物分子电子学并为单分子生物物理学和生物医学开辟新的前景。在这里，我们提供了一个简单的介绍和概述的生物分子电子学领域，专注于核酸和这些测量的潜在应用。特别是，我们回顾了最近的演示的第一个单分子电检测的生物相关的核酸。我们还展示了如何将其用于研究生物分子的相互作用和在早期癌症检测的液体活检中的应用。最后，我们讨论了未来的前景和挑战，在这个迷人的研究领域的应用。
The last half-century has witnessed the birth and development of a new multidisciplinary field at the edge between materials science, nanoscience, engineering, and chemistry known as Molecular Electronics. This field deals with the electronic properties of individual molecules and their integration as active components in electronic circuits and has also been applied to biomolecules, leading to BioMolecular Electronics and opening new perspectives for single-molecule biophysics and biomedicine. Herein, we provide a brief introduction and overview of the BioMolecular electronics field, focusing on nucleic acids and potential applications for these measurements. In particular, we review the recent demonstration of the first single-molecule electrical detection of a biologically-relevant nucleic acid. We also show how this could be used to study biomolecular interactions and applications in liquid biopsy for early cancer detection, among others. Finally, we discuss future perspectives and challenges in the applications of this fascinating research field.