DIETARY NICOTINE - A SOURCE OF URINARY COTININE
DIETARY NICOTINE - A SOURCE OF URINARY COTININE
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DOI：
10.1016/0278-6915(91)90109-k
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发表时间：
1991-12-01
影响因子：
4.3
通讯作者：
REYNOLDS, JH
中科院分区：
文献类型：
--
作者：
DAVIS, RA;STILES, MF;REYNOLDS, JH
主要来自茄科植物的食物和一些茶被检查是否存在尼古丁。膳食尼古丁会导致尿液中的可替宁，并影响依赖于尿液中可替宁的烟草烟雾暴露估计值。对所有食物进行均质化、提取，并通过气相色谱氮敏检测（GC）和/或GC/MS（质谱）分析尼古丁和可替宁。以类似的方式分析茶的弱酸和水提取物。在茄子或绿色辣椒中未检测到尼古丁（< 1 ng/ml提取物）。番茄和马铃薯中尼古丁的平均值分别为7.3 ng/g湿重和15 ng/g湿重。红茶，包括常规和无咖啡因的品牌，尼古丁含量从不可检测到> 100 ng/g湿重。速溶茶产生的尼古丁含量最高（高达285纳克/克湿重）。这些食物中尼古丁的可能来源进行了讨论。根据这些食物和饮料的估计平均和最大消耗量计算尿可替宁浓度的潜在值范围（0.6至6.2 ng/ml）。由于通过这些途径暴露于尼古丁的可能性，尿可替宁作为暴露于环境烟草烟雾的生物标志物的使用可能会受到影响。
Foods, principally from plants in the family Solanaceae, and a number of teas were examined for the presence of nicotine. Dietary nicotine would give rise to cotinine in urine and compromise estimates of exposure to tobacco smoke that depend on urinary cotinine. All foods were homogenized, extracted and analysed for nicotine and cotinine by gas chromatography with nitrogen-sensitive detection (GC) and/or GC/MS (mass spectrometry). Weak acid and aqueous extracts of the teas were analysed in a similar manner. Nicotine was not detected (< 1 ng/ml of extract) in egg plant or green pepper. The average values for nicotine in tomato and potato were 7.3 ng/g wet weight and 15 ng/g wet weight, respectively. Black teas, including regular and decaffeinated brands, had nicotine contents ranging from non-detectable to > 100 ng/g wet weight. Instant teas yielded the highest nicotine contents observed (up to 285 ng/g wet weight). The possible sources of nicotine in these foods are discussed. A range of potential values for urinary cotinine concentrations (0.6 to 6.2 ng/ml) was calculated based upon estimated average and maximal consumptions of these foods and beverages. Because of the potential for exposure to nicotine by way of these routes, the use of urinary cotinine as a biomarker of exposure to environmental tobacco smoke may be compromised.