Subject's own name as a novel in a MMN design:: A combined ERP and PET study
Subject's own name as a novel in a MMN design:: A combined ERP and PET study
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DOI：
10.1016/j.brainres.2007.10.091
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发表时间：
2008-01-16
期刊：
影响因子：
2.9
通讯作者：
Mauguiere, Francois
中科院分区：
文献类型：
--
作者：
Holeckova, Irena;Fischer, Catherine;Mauguiere, Francois
为了开发一种临床工具来评估脑损伤患者的认知功能，我们之前在清醒的健康人身上展示了他们对自己的名字（SON）的反应特征模式（32个电极），以被动的古怪范式呈现。在目前的ERP和PET联合研究中，为了试图确定MMN持续时间和对熟悉声音（FV）或未知声音（NFV）发出的SON的反应的大脑相关性，我们使用了尽可能接近上述SON协议的块设计协议。ERP数据显示持续时间MMN和新颖性P3对SON的反应与我们之前的结果相似。PET技术不允许真正的MMN产生者被披露，但与没有偏差的控制条件相比，具有持续偏差的脑块引起了右侧颞极激活的增加，这支持了右半球在早期声音辨别中占优势的假设。在SON对比中，颞叶、额叶和顶叶皮质、海马体和楔前叶的强劲脑血流激活可能与语言、新奇和自我识别处理有关。熟悉和不熟悉的声音对前额叶皮层的激活不同，表明不同的检索过程，尽管相应的ERP反应无法区分。(c) 2007 Elsevier B.V.版权所有
With a view to elaborating a clinical tool to assess cognitive functions in brain-damaged patients, we had previously displayed characteristic patterns of ERPs (32 electrodes) in awake healthy persons in response to their own name (SON) presented as a novel in a passive oddball paradigm. In the present combined ERP and PET study, in an attempt to identify brain correlates of duration MMN and response to SON uttered by a familiar (FV) or an unknown voice (NFV), we used a block design protocol as close as possible to the aforementioned SON protocol. ERP data showed robust duration MMN and novelty P3 in response to SON similar to our previous results. The PET technique did not allow true MMN generators to be disclosed, but blocks with duration deviants elicited an increase of activation in the right temporal pole as compared with the control condition with no deviants, supporting the hypothesis of right hemispheric dominance in early sound discrimination. For SON contrasts, robust cerebral blood flow activation present over temporal, frontal and parietal cortices, in the hippocampus and in the precuneus could be associated with speech, novelty and self-recognition processing. Familiar and unfamiliar voices activated the prefrontal cortex differently, suggesting different retrieval processes, although corresponding ERP responses could not be differentiated. (c) 2007 Elsevier B.V. All rights reserved.