Improved first-pass spiral myocardial perfusion imaging with variable density trajectories.

Improved first-pass spiral myocardial perfusion imaging with variable density trajectories.
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DOI:
10.1002/mrm.24569
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发表时间:
2013-11
影响因子:
3.3
通讯作者:
Meyer, Craig H.
Meyer, Craig H.
中科院分区:
医学3区
文献类型:
--
作者:
Salerno, Michael;Sica, Christopher;Kramer, Christopher M.;Meyer, Craig H.

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开发和评估可变密度 (VD) 螺旋首过灌注脉冲序列,以提高效率和偏共振性能,并演示变迹密度补偿函数 (DCF) 在提高 SNR 和减少由心脏运动和吉布斯振铃引起的暗边缘伪影方面的实用性。在 1.5T 扫描仪上设计、模拟和评估了 18 名正常受试者和 8 名心脏病患者的三个可变密度螺旋轨迹。通过利用有意对 k 空间数据进行变迹的密度补偿函数 (DCF),与使用传统 VD DCF 校正的相同数据相比,理论 PSF 的旁瓣幅度降低了 68%,而主瓣的 FWHM 仅增加了 13%,并且与具有相同交错数和读出持续时间的均匀密度螺旋相比,分辨率提高了 8%。此外,与使用传统 DCF 校正的相同 VD 螺旋数据相比,该策略使测量的 SNR 增加了 60% 以上 (p<0.01)。可以清晰地看到灌注缺陷,同时将偏共振和暗边伪影降至最低。使用变迹 DCF 的 VD 螺旋脉冲序列可生成高质量的首次通过灌注图像,具有最小的暗边缘和偏共振伪影、高 SNR 和 CNR 以及对静息灌注异常的良好描绘。
To develop and evaluate variable-density (VD) spiral first-pass perfusion pulse sequences for improved efficiency and off-resonance performance and to demonstrate the utility of an apodizing density compensation function (DCF) to improve SNR and reduce dark-rim artifact caused by cardiac motion and Gibbs Ringing. Three variable density spiral trajectories were designed, simulated, and evaluated in 18 normal subjects, and in 8 patients with cardiac pathology on a 1.5T scanner. By utilizing a density compensation function (DCF) which intentionally apodizes the k-space data, the side-lobe amplitude of the theoretical PSF is reduced by 68%, with only a 13% increase in the FWHM of the main-lobe as compared to the same data corrected with a conventional VD DCF, and has an 8% higher resolution than a uniform density spiral with the same number of interleaves and readout duration. Furthermore, this strategy results in a greater than 60% increase in measured SNR as compared to the same VD spiral data corrected with a conventional DCF (p<0.01). Perfusion defects could be clearly visualized with minimal off-resonance and dark-rim artifacts. VD spiral pulse sequences using an apodized DCF produce high-quality first-pass perfusion images with minimal dark-rim and off-resonance artifacts, high SNR and CNR and good delineation of resting perfusion abnormalities.
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