Longitudinal fMRI study of reading in a patient with letter-by-letter reading
Longitudinal fMRI study of reading in a patient with letter-by-letter reading
复制标题
逐字阅读患者阅读的纵向功能磁共振成像研究
DOI：
10.1016/j.cortex.2007.03.002
复制
发表时间：
2008
期刊：
影响因子：
3.6
通讯作者：
H. Fukuyama
中科院分区：
文献类型：
--
作者：
T. Ino;K. Tokumoto;K. Usami;Toru Kimura;Yoichi Hashimoto;H. Fukuyama
本研究提供了一项纵向功能磁共振成像研究，在左侧基底枕颞区出血后 7 天，患者显示逐字 (LBL) 读数，并在发病后 50 天，当他的 LBL 读数消失时再次重复。两次治疗的直接比较表明，当他持续进行 LBL 阅读时，所谓的视觉词形区 (VWFA) 的右侧同源区，以及与语言和言语工作记忆相关的网络，如双侧前运动区、布罗卡区及其右侧同源区以及左侧辅助运动区，在他恢复时比恢复时激活得更强烈，而 VWFA 周围的病变周围活动和左上顶小叶上部的活动在恢复时比恢复时激活得更强烈。当他的 LBL 阅读持续存在时。这些结果表明，大脑的动态功能重组是在急性期引起的，除了 VWFA 之外，左顶上小叶某些区域的激活增加可能与 LBL 阅读的恢复有关。
The present study provides a longitudinal fMRI study of reading 7 days after a hemorrhage in the left basal occipito-temporal region when the patient showed letter-by-letter (LBL) reading, and repeated again 50 days after onset, when his LBL reading had resolved. Direct comparison of the two sessions showed that right homologue of the so called visual word form area (VWFA), as well as a network related to language and verbal working memory, such as the bilateral premotor areas, Broca's area and its right homologue, and the left supplementary motor area were more strongly activated when his LBL reading persisted than when he recovered, whereas perilesional activity around the VWFA and the activity of superior part of the left superior parietal lobule were more strongly activated when he recovered than when his LBL reading persisted. These results suggest that dynamic functional reorganization of the brain was caused in the acute phase and that the increased activation of certain areas in the left superior parietal lobule in addition to the VWFA may be related to recovery from LBL reading.