Magnesium Homeostasis in Mammalian Cells
Magnesium Homeostasis in Mammalian Cells
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DOI：
10.1007/978-94-007-5561-1_4
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发表时间：
2013-01-01
期刊：
影响因子：
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通讯作者：
Romani, Andrea M. P.
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文献类型：
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作者：
Romani, Andrea M. P.
镁是细胞内第二丰富的阳离子，在许多生物功能中发挥着重要作用。实验证据表明，哺乳动物细胞通过特定的机制来控制细胞内镁离子的含量，这些机制控制着镁离子跨细胞膜和各种细胞器的进入和流出，以及在静息条件下和激素和代谢刺激下的细胞内镁离子缓冲。本章将对控制细胞内镁稳态和运输的各种机制进行评估，以及细胞内镁含量的变化在生理和病理条件下所起的作用。
Magnesium, the second most abundant cation within the cell, plays an important role in numerous biological functions. Experimental evidence indicates that mammalian cells tightly regulate cellular magnesium ion content through specific mechanisms controlling Mg2+ entry and efflux across the cell membrane and the membrane of various cellular organelles as well as intracellular Mg2+ buffering under resting conditions and following hormonal and metabolic stimuli. This chapter will provide an assessment of the various mechanisms controlling cellular Mg2+ homeostasis and transport, and the implications changes in cellular Mg2+ content play under physiological and pathological conditions.