Comparison of Semi-automatic Volumetric VX2 Hepatic Tumor Segmentation from Cone Beam CT and Multi-detector CT with Histology in Rabbit Models
Comparison of Semi-automatic Volumetric VX2 Hepatic Tumor Segmentation from Cone Beam CT and Multi-detector CT with Histology in Rabbit Models
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DOI：
10.1016/j.acra.2012.07.011
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发表时间：
2013-01-01
影响因子：
4.8
通讯作者：
Geschwind, Jean-Francois
中科院分区：
文献类型：
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作者：
Pellerin, Olivier;Lin, MingDe;Geschwind, Jean-Francois
理由和目的：本研究的目的是比较c臂锥束计算机断层扫描（CBCT）和多探测器计算机断层扫描（MDCT）采用半自动肿瘤分割计算的VX2兔模型的肿瘤体积与实际肿瘤体积。材料与方法：对20只成年雄性新西兰兔（每兔1只）20个VX2肿瘤进行CBCT（动脉内注射造影剂）和MDCT（静脉注射造影剂）成像。所有肿瘤体积均采用半自动三维体积分割软件测量。该软件使用非欧几里得径向基函数的区域生长方法。成像后，切除肿瘤进行病理体积测量，采用线性回归、Pearson检验和Bland Altman分析将基于成像的肿瘤体积测量与病理体积进行比较。结果：病理上平均肿瘤体积为3.5 +/- 1.6 cm(3)（范围为1.4-7.2 cm(3)）， CBCT上为3.8 +/- 1.6 cm(3)（范围为1.3-7.3 cm(3)）， MDCT上为3.9 +/- 1.6（范围为1.8-7.5 cm(3)） （P < 0.001）。病理体积与CBCT和MDCT之间存在很强的相关性（CBCT和MDCT的Pearson相关系数分别为0.993和0.996,P < 0.001）。Bland-Altman分析显示，MDCT有高估肿瘤体积的倾向，CBCT与病理对肿瘤体积的吻合度高于MDCT，这可能与动脉内注射造影剂有关。结论：采用半自动肿瘤分割软件测量的肿瘤体积与病理测量的“真实体积”具有较强的相关性。CBCT和MDCT上的分割软件可作为肝肿瘤体积评估的有用工具。
Rationale and Objectives: The purpose of this study was to compare tumor volume in a VX2 rabbit model as calculated using semiautomatic tumor segmentation from C-arm cone-beam computed tomography (CBCT) and multidetector computed tomography (MDCT) to the actual tumor volume.Materials and Methods: Twenty VX2 tumors in 20 adult male New Zealand rabbits (one tumor per rabbit) were imaged with CBCT (using an intra-arterial contrast medium injection) and MDCT (using an intravenous contrast injection). All tumor volumes were measured using semiautomatic three-dimensional volumetric segmentation software. The software uses a region growing method using non-Euclidean radial basis functions. After imaging, the tumors were excised for pathologic volume measurement The imaging based tumor volume measurements were compared to the pathologic volumes using linear regression, with Pearson's test, and correlated using Bland Altman analysis.Results: Average tumor volumes were 3.5 +/- 1.6 cm(3) (range, 1.4-7.2 cm(3)) on pathology, 3.8 +/- 1.6 cm(3) (range, 1.3-7.3 cm(3)) on CBCT, and 3.9 +/- 1.6 (range, 1.8-7.5 cm(3)) on MDCT (P < .001). A strong correlation between volumes on pathology and CBCT and also with MDCT was observed (Pearson's correlation coefficient = 0.993 and 0.996, P < .001, for CBCT and MDCT, respectively). Bland-Altman analysis showed that MDCT tended to overestimate tumor volume, and there was stronger agreement for tumor volume between CBCT and pathology than with MDCT, possibly because of the intra-arterial contrast injection.Conclusions: Tumor volume as measured using semiautomatic tumor segmentation software showed a strong correlation with the "real volume" measured on pathology. The segmentation software on CBCT and MDCT can be a useful tool for volumetric hepatic tumor assessment.