Biofortification of plant-based food: Enhancing folate levels by metabolic engineering
Biofortification of plant-based food: Enhancing folate levels by metabolic engineering
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DOI：
10.1073/pnas.0700640104
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发表时间：
2007-03
期刊：
影响因子：
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通讯作者：
D. DellaPenna
中科院分区：
文献类型：
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作者：
D. DellaPenna
人类需要每天摄入最低限度的必需微量营养素、维生素和矿物质来保持最佳健康状态。微量营养素营养不良，即饮食中缺乏一种或多种微量营养素，在生命的各个阶段对健康产生深远的负面影响，在20世纪初是所有国家普遍存在的健康问题。在发达国家，由于20世纪中期建立的项目，在加工食品中添加必要的微量营养素，这些人口的微量营养素营养不良得到了显著缓解。类似的强化措施在发展中国家只取得了有限的成功，因为许多目标国家需要的农业、食品加工和分销的工业水平有限或缺乏。因此，微量营养素营养不良在发展中国家仍然是一个广泛而持久的全球健康问题，它继续给个人、人口和社会造成巨大的损失(1)。
Humans require a minimum daily intake of essential micronutrients, vitamins, and minerals to maintain optimal health. Micronutrient malnutrition, the dietary insufficiency of one or more micronutrients, has far-reaching negative health consequences at all stages of life and was a pervasive health issue for all countries at the turn of the 20th century. Micronutrient malnutrition has been significantly alleviated for those populations in developed countries as a result of programs established in the mid-20th century that fortified processed foods with the necessary micronutrients. Similar fortification efforts have had only modest success in developing countries because an industrial level of agriculture, food-processing, and distribution that is limited or lacking in many of the targeted countries is required. Micronutrient malnutrition thus has remained a widespread and persistent global health problem in developing countries where it continues to exact an enormous toll on individuals, populations, and society (1).