RELATION OF CAMPYLOBACTER-PYLORIDIS TO GASTRITIS AND PEPTIC-ULCER
RELATION OF CAMPYLOBACTER-PYLORIDIS TO GASTRITIS AND PEPTIC-ULCER
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DOI：
10.1093/infdis/153.4.664
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发表时间：
1986-04-01
影响因子：
6.4
通讯作者：
DINUZZO, AR
中科院分区：
文献类型：
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作者：
BUCK, GE;GOURLEY, WK;DINUZZO, AR
对50例上消化道疾病患者的胃窦粘膜活检标本进行了光镜、电镜和培养观察。在46个可评估的样本中，7个组织学正常，39个显示胃炎的证据。27例有胃炎证据的标本（69%）含有螺旋菌，而只有1例正常标本（14%）含有这些细菌（P = 0.02）。在17例胃溃疡患者中，10例（59% [P > .10]）同时存在螺旋菌。可以看到细菌散布在上皮细胞表面和粘液层下方，但很少在上皮细胞内部发现。在微需氧条件下于37 ℃在巧克力琼脂上培养的10个样本中分离出弯曲或螺旋形革兰氏阴性杆菌。这种细菌类似于最近被其他研究人员命名为幽门弯曲杆菌的有机体。
Biopsy specimens from the gastric antral mucosa of 50 patients with upper gastrointestinal complaints were studied by light and electron microscopy and culture. Of 46 assessable specimens, seven were histologically normal, and 39 showed evidence of gastritis. Twenty-seven of the specimens with evidence of gastritis (69%) contained spiral bacteria, whereas only one of the normal specimens (14%) contained these bacteria (P = .02). Of 17 patients found to have gastric ulcers, 10 (59% [P > .10]) also had spiral bacteria. The bacteria could be seen scattered over the surface of the epithelial cells and just under the layer of mucus but were rarely found inside the epithelial cells. Curved or spiral gram-negative bacilli were isolated from 10 of the specimens on chocolate agar incubated at 37 C under microaerophilic conditions. The bacteria resembled the organism recently named Campylobacter pyloridis by other investigators.