Effect of diterpenoid alkaloids on cardiac sympathetic efferent and vagal afferent nerve activity.
Effect of diterpenoid alkaloids on cardiac sympathetic efferent and vagal afferent nerve activity.
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DOI：
10.1016/0014-2999(95)00290-2
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发表时间：
1995-09
影响因子：
5
通讯作者：
H. Chiao;S. Pelletier;H. Desai;W. R. Rebagay;R. Caldwell
中科院分区：
文献类型：
--
作者：
H. Chiao;S. Pelletier;H. Desai;W. R. Rebagay;R. Caldwell
二萜类生物碱高乌甲素在150 μg/kg（i. v.）心迷走神经传入活动增加（16.2%），心交感神经传出活动减少（12.5%）。极性类似物N-去乙酰基乌甲素在相同剂量下可增加心脏迷走神经传入神经活动（40%），减少心脏交感神经传出神经活动（23.5%）。这两种药物也降低了动脉血压和心率。大剂量高乌甲素（300 μg/kg i. v.）在神经活动和心脏功能方面产生了与较低剂量相同的变化。另外两种结构相关的药物，石蒜酮碱和乌头碱，在剂量高达300 μg/kg时未能改变这些变量。这些数据表明，某些二萜生物碱激活自主反射受体，包括心脏反射受体。极性剂N-去乙酰基高乌甲素似乎比非极性剂高乌甲素对心脏反射受体更有效。此类药剂可用于治疗高血压。
The diterpenoid alkaloid, lappaconitine, at a dose of 150 μg/kg (i.v.) increased cardiac vagal afferent nerve activity (16.2%) and reduced cardiac sympathetic efferent nerve activity (12.5%). A polar analog, N-deacetyllappaconitine, at this same dose, increased cardiac vagal afferent nerve activity (40%) and reduced cardiac sympathetic efferent nerve activity (23.5%). Both of these agents also reduced arterial blood pressure and heart rate. A larger dose of lappaconitine (300 μg/kg i.v.) produced the same changes in nerve activities and cardiac function as the lower dose. Two other structurally related agents, lycoctonine and aconine, failed to alter these variables in doses up to 300 μg/kg. These data suggest that certain diterpenoid alkaloids activate autonomic reflex receptors, including cardiac reflex receptors. The polar agent, N-deacetyllappaconitine, appears to be more effective on cardiac reflex receptors than the non-polar agent, lappaconitine. Such agents may be useful in the treatment of hypertension.