Low-dose aspirin therapy improves decidual arteriopathy in pregnant women with a history of preeclampsia
Low-dose aspirin therapy improves decidual arteriopathy in pregnant women with a history of preeclampsia
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小剂量阿司匹林治疗可改善有先兆子痫病史的孕妇的蜕膜动脉病
DOI：
10.1007/s00428-022-03388-3
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Sato Y
中科院分区：
文献类型：
--
作者：
Tomimori-Gi K;Katsuragi S;Kodama Y;Yamada N;Sameshima H;Maekawa K;Yamashita A;Gi T;Sato Y
先兆子痫是一种多系统妊娠特异性高血压疾病，会导致显着的孕产妇和围产期发病率和死亡率。这种情况与胎盘组织病理学异常有关，特别影响蜕膜螺旋动脉。据报道，阿司匹林可以预防先兆子痫，特别是早发性先兆子痫，尽管接受阿司匹林治疗的女性蜕膜动脉的研究结果仍不清楚。我们比较了有先兆子痫病史、接受和未接受低剂量阿司匹林治疗的女性（分别为 LDA 组和非 LDA 组）的临床和组织病理学胎盘结果。我们确定了 26 名有先兆子痫病史的女性； 9 名女性接受了 LDA（阿司匹林≤100 mg/天，在 16 周开始，LDA 组），17 名女性未接受 LDA（非 LDA 组）。与非 LDA 组相比，LDA 组的平均孕龄较高（36.7 周 vs. 32.3 周，P= 0.0221），子痫前期发生率较低（11% vs. 59%，P= 0.0362）。组织病理学上，LDA组蜕膜动脉病的发生率，特别是纤维蛋白样坏死和血栓形成的发生率低于非LDA组（44% vs. 88%，P= 0.0283）。免疫组织学上，LDA 组的内皮标志物（CD31 和 CD39）表达强于非 LDA 组。值得注意的是，我们观察到炎症变化（慢性血管周围炎、蛋白酶激活受体 1 表达和 CD3 阳性细胞）没有显着的组间差异。这项研究强调，LDA 可抑制高血压引起的内皮损伤和血栓形成，从而保护母体胎盘灌注并预防先兆子痫。
Preeclampsia, a multisystem pregnancy-specific hypertensive disorder, results in significant maternal and perinatal morbidity and mortality. This condition is associated with placental histopathological abnormalities and particularly affects the decidual spiral arteries. Reportedly, aspirin prevents preeclampsia, specifically early-onset preeclampsia, although findings in decidual arteries in women treated with aspirin therapy remain unclear. We compared the clinical and histopathological placental findings between women with a history of preeclampsia, who did and did not receive low-dose aspirin therapy (LDA and non-LDA groups, respectively). We identified 26 women with a history of preeclampsia; 9 women received LDA (aspirin ≤ 100 mg/day, initiated at < 16 weeks, LDA group), and 17 women did not receive LDA (non-LDA group). The mean gestational age was higher (36.7 weeks vs. 32.3 weeks,P= 0.0221) and the incidence of preeclampsia was lower (11% vs. 59%,P= 0.0362) in the LDA than in the non-LDA group. Histopathologically, the incidence of decidual arteriopathy, particularly that of fibrinoid necrosis and thrombosis, was lower in the LDA than in the non-LDA group (44% vs. 88%,P= 0.0283). Immunohistologically, endothelial marker (CD31 and CD39) expression was stronger in the LDA than in the non-LDA group. Notably, we observed no significant intergroup differences in inflammatory changes (chronic perivasculitis, protease-activated receptor 1 expression, and CD3-positive cells). This study highlights that LDA inhibits hypertension-induced endothelial injury and thrombosis, and thereby protects maternal placental perfusion and prevents preeclampsia.
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[母体血管灌注不良]。
DOI：
--
发表时间：
2020
期刊：
Zhonghua bing li xue za zhi = Chinese journal of pathology
影响因子：
--
作者：
D. Zhang;L. Zhang;C. Zhao
通讯作者：
C. Zhao
既往妊娠结局不佳的女性的低剂量阿司匹林治疗和胎盘病理学
影响因子：
3.6
作者：
W. Cusick;C. Salafia;Linda Ernst;J. Rodis;W. Campbell;A. Vintzileos
通讯作者：
A. Vintzileos
CD39 过度表达可保护先兆子痫小鼠模型
影响因子：
2.5
作者：
J. McRae;P. Russell;Joanne S. J. Chia;K. Dwyer
通讯作者：
K. Dwyer
阿司匹林对不良产科病史患者胎盘和围产期结局的影响
影响因子：
2.6
作者：
E. Tarım;N. Bal;E. Kılıçdağ;F. Kayaselçuk;T. Bağış;E. Kuşçu
通讯作者：
E. Kuşçu
影响因子：
15.9
作者：
Zhou, Y;Damsky, CH;Fisher, SJ
通讯作者：
Fisher, SJ