A preliminary evaluation of VEGF-A, VEGFR1 and VEGFR2 in patients with well-controlled type 2 diabetes mellitus
A preliminary evaluation of VEGF-A, VEGFR1 and VEGFR2 in patients with well-controlled type 2 diabetes mellitus
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DOI：
10.1631/jzus.b1400024
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发表时间：
2014-06-01
影响因子：
5.1
通讯作者：
Rosc, Danuta
中科院分区：
文献类型：
--
作者：
Ruszkowska-Ciastek, Barbara;Sokup, Alina;Rosc, Danuta
失代偿性慢性高血糖症通常会导致晚期微血管并发症，例如视网膜病变、糖尿病足综合征和糖尿病肾病。为探讨糖尿病控制良好患者血管内皮生长因子A（VEGF-A）及其受体的变化，对31例无微血管或大血管病变的2型糖尿病患者进行了研究。30例健康志愿者作为对照组。检测VEGF-A、VEGF受体1和2（VEGFR 1和VEGFR 2）、空腹血糖、血脂和糖化血红蛋白（HbA 1c）浓度，两组间VEGF-A、VEGFR 1和VEGFR 2浓度无显著性差异。在研究组中，VEGF-A、VEGFR 2和甘油三酯的水平之间存在正相关性，VEGFR 2和高密度脂蛋白（HDL）-胆固醇的水平之间存在负相关性。控制良好的糖尿病患者的VEGF-A及其受体1和2的浓度与健康个体的浓度相当，这可能表明葡萄糖水平的适当控制延迟了血管并发症的发生。VEGFR 2和HDL-胆固醇水平之间的负相关性，以及VEGF-A、VEGFR 2和甘油三酯水平之间的正相关性，表明糖尿病中发生的脂质异常可能参与血管生成的调节。
Decompensated chronic hyperglycemia often leads to late microvascular complications such as retinopathy, diabetic foot syndrome, and diabetic kidney disease. The aim of this study was to determine the concentration of vascular endothelial growth factor A (VEGF-A) and its receptors in patients with well-controlled diabetes.The study was conducted on 31 patients with well-controlled type 2 diabetes without micro-or macroangiopathy. Thirty healthy volunteers were enrolled in a control group. Serum concentrations of VEGF-A, VEGF receptors 1 and 2 (VEGFR1 and VEGFR2), fasting glucose, and lipid profiles were measured, and the plasma concentration of glycated hemoglobin (HbA1c) was determined.No significant differences were observed between the concentration of VEGF-A, VEGFR1 or VEGFR2 in the subject group and that in the control group. Positive correlations were noted between the levels of VEGF-A, VEGFR2, and triglyceride, and there was a negative correlation between the levels of VEGFR2 and high-density lipoprotein (HDL)-cholesterol in the study group.The concentrations of VEGF-A and its receptors 1 and 2 in patients with well-controlled diabetes are comparable to those of healthy individuals, which may indicate that appropriate control of glucose levels delays the occurrence of vascular complications. A negative correlation between VEGFR2 and HDL-cholesterol levels, and positive correlations between VEGF-A, VEGFR2, and triglyceride levels, suggest that lipid abnormalities occurring in diabetes may be involved in the modulation of angiogenesis.