Endometriosis-associated ovarian carcinoma - Differential expression of vascular endothelial growth factor and estrogen/progesterone receptors
Endometriosis-associated ovarian carcinoma - Differential expression of vascular endothelial growth factor and estrogen/progesterone receptors
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DOI：
10.1002/cncr.11714
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发表时间：
2003-10-15
期刊：
影响因子：
6.2
通讯作者：
Bristow, RE
中科院分区：
文献类型：
--
作者：
del Carmen, MG;Sehdev, AES;Bristow, RE
背景多项流行病学和组织学研究表明，卵巢子宫内膜异位症可引起恶性卵巢肿瘤，主要是上皮起源的肿瘤。子宫内膜异位症进展为卵巢癌相关性卵巢癌（EAOC）尚未得到彻底的研究，充其量也是知之甚少。免疫组织化学。方法比较不典型子宫内膜异位症（AE）和EAOC中多种细胞因子和生长因子的差异表达。使用约翰霍普金斯病理学数据库，鉴定来自诊断为EAOC或AE的患者的组织块。对组织块进行4种标记物染色：血管内皮生长因子（VEGF）、Ki-67、雌激素受体（ER）和孕激素受体（PR）。确定了17例EAOC和8例AE。在17个EAOC组织块中的16个（94%）和8个AE组织块中的仅1个（12.5%）中记录了VEGF染色（P < 0.0001）。17个EAOC组织块中只有4个（23%）显示ER阳性染色，而8个AE组织块中有8个（100%）显示ER阳性染色（P = 0.0005）。仅在17份EAOC样本中的6份（35%）中观察到PR阳性染色，但在8份AE样本中的8份（100%）中存在PR阳性染色（P = 0.003）。70%的EAOC标本Ki-67表达阳性，而AE标本Ki-67表达阳性率为37.5%（P = 0.19）。EAOC似乎与VEGF的过度表达和ER和PR的表达减少有关。VEGF表达的变化可能与子宫内膜异位症的恶性转化有关，并可能为卵巢恶性肿瘤的治疗提供诊断和治疗选择。(C)2003年美国癌症协会。
BACKGROUND. Multiple epidemiologic and histologic studies have suggested that ovarian endometriosis can give rise to malignant ovarian tumors, primarily those of epithelial origin. The progression of endometriosis to endometriosis-associated ovarian carcinoma (EAOC) has not been investigated thoroughly and is poorly understood at best. Using immunohistochemical. methods, we compared the differential expression patterns of various cytokines and growth factors in atypical endometriosis (AE) and EAOC.METHODS. Using the Johns Hopkins Pathology Data Bank, tissue blocks from patients diagnosed with EAOC or AE were identified. Tissue blocks were stained for 4 markers: vascular endothelial growth factor (VEGF), Ki-67, estrogen receptor (ER), and progesterone receptor (PR).RESULTS. Seventeen cases of EAOC and 8 cases of AE were identified. Staining for VEGF was documented in 16 of 17 (94%) EAOC tissue blocks and in only 1 of 8 (12.5%) AE tissue blocks (P < 0.0001). Only 4 of the 17 (23%) EAOC tissue blocks exhibited positive staining for ER, compared with 8 of 8 (100%) AE tissue blocks (P = 0.0005). Positive staining for PR was noted in only 6 of 17 (35%) EAOC samples but was present in 8 of 8 (100%) AE samples (P = 0.003). Seventy percent of EAOC samples exhibited positive staining for Ki-67, compared with 37.5% of AE samples (P = 0.19).CONCLUSIONS. EAOC appears to be associated with overexpression of VEGF and reduced expression of both ER and PR. Variations in VEGF expression may be associated with the malignant transformation of endometriosis and may present both diagnostic and therapeutic options for the treatment of ovarian malignancies. (C) 2003 American Cancer Society.