High L-Type Amino Acid Transporter 1 Levels Are Associated with Chemotherapeutic Resistance in Gastric Cancer Patients
High L-Type Amino Acid Transporter 1 Levels Are Associated with Chemotherapeutic Resistance in Gastric Cancer Patients
复制标题
DOI：
10.1159/000517371
复制
发表时间：
2021-08-13
期刊：
影响因子：
3.5
通讯作者：
Saeki, Hiroshi
中科院分区：
文献类型：
--
作者：
Nakazawa, Nobuhiro;Sohda, Makoto;Saeki, Hiroshi
前言：我们研究了l型氨基酸转运蛋白1 （lat1）在临床胃癌（GC）患者中的表达是否可以预测患者对术后辅助化疗的治疗反应。方法：采用免疫组化方法检测111例胃癌患者中lat1、CD98和雷帕霉素磷酸化靶蛋白（p-mTOR）的表达。为了阐明lat1是否影响化疗的疗效，我们将59例术后未进行辅助化疗的患者和52例术后进行辅助化疗的患者分为两组，测定无病生存率与lat1的相关性。结果：lat1与CD98、p-mTOR表达显著相关。在未治疗组中，我们未发现lat1与复发之间有统计学意义的相关性。相比之下，在化疗组中，lat1表达与无病生存之间存在显著关联。此外，多因素回归分析表明，lat1是术后辅助化疗组无病生存的独立预测因子（p = 0.012）。结论：我们的研究结果表明，lat1是术后辅助化疗成功的一个有用的预测指标。
Introduction: We investigated whether the expression of L-type amino acid transporter 1 (LAT-1) in clinical gastric cancer (GC) patients could predict patient therapeutic response to postoperative adjuvant chemotherapy. Methods: Immunohistochemistry was used to investigate LAT-1, CD98, and phosphorylated-mammalian target of rapamycin (p-mTOR) expression in 111 GC patients. To clarify whether LAT-1 influences the therapeutic effects of chemotherapy, the correlation between disease-free survival rates and LAT-1 was determined in 2 groups: 59 patients who did not undergo postoperative adjuvant chemotherapy and 52 patients who did undergo postoperative adjuvant chemotherapy. Results: LAT-1 was significantly correlated with CD98 and p-mTOR expressions. We did not find any statistically significant correlation between LAT-1 and recurrence in the nontreated group. In contrast, a significant association was found between LAT-1 expression and disease-free survival in the chemotherapy group. Moreover, multivariate regression analysis demonstrated that LAT-1 was an independent predictor of disease-free survival in the postoperative adjuvant chemotherapy group (p = 0.012). Conclusion: Our findings demonstrate that LAT-1 is a useful predictive marker for a successful postoperative adjuvant chemotherapy treatment.