Genetic structure in the Sherpa and neighboring Nepalese populations.
Genetic structure in the Sherpa and neighboring Nepalese populations.
复制标题
夏尔巴省和邻近尼泊尔人口中的遗传结构。
DOI：
10.1186/s12864-016-3469-5
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发表时间：
2017-01-19
期刊：
影响因子：
4.4
通讯作者：
Cavalleri GL
中科院分区：
文献类型：
--
作者：
Cole AM;Cox S;Jeong C;Petousi N;Aryal DR;Droma Y;Hanaoka M;Ota M;Kobayashi N;Gasparini P;Montgomery H;Robbins P;Di Rienzo A;Cavalleri GL
我们开始描述尼泊尔东部地区的精细人口结构。迄今为止，居住在尼泊尔的夏尔巴人的遗传结构以及他们与尼泊尔人的亲缘关系知之甚少。我们收集了代表尼泊尔和大喜马拉雅地区包括西藏、中国、印度、巴基斯坦、哈萨克斯坦、乌兹别克斯坦、塔吉克斯坦和吉尔吉斯斯坦在内的各种不同人群的1245个个体的密集基因数据。我们进行了主成分分析、混合分析和纯合性分析。我们在居住在喜马拉雅弧形地区的种群中发现了明显的亚结构，其遗传结构大致反映了该地区的地理特征。在混合分析和主成分分析中，尼泊尔境内的族裔亚群表现出明显的遗传结构。我们在尼泊尔各亚群中发现了来自北喜马拉雅种群的不同比例的祖先，其中尼泊尔的Rai、Magar和Tamang具有最大比例的藏族祖先。我们表明，居住在喜马拉雅高原的人口已经对北印度基因库产生了明显的影响。我们说明了夏尔巴人是一个非常孤立的群体，几乎没有来自周围尼泊尔人的基因流动。本文的在线版本(doi：10.1186/s12864-0163469-5)包含补充材料，授权用户可以使用。
We set out to describe the fine-scale population structure across the Eastern region of Nepal. To date there is relatively little known about the genetic structure of the Sherpa residing in Nepal and their genetic relationship with the Nepalese. We assembled dense genotype data from a total of 1245 individuals representing Nepal and a variety of different populations resident across the greater Himalayan region including Tibet, China, India, Pakistan, Kazakhstan, Uzbekistan, Tajikistan and Kirghizstan. We performed analysis of principal components, admixture and homozygosity. We identified clear substructure across populations resident in the Himalayan arc, with genetic structure broadly mirroring geographical features of the region. Ethnic subgroups within Nepal show distinct genetic structure, on both admixture and principal component analysis. We detected differential proportions of ancestry from northern Himalayan populations across Nepalese subgroups, with the Nepalese Rai, Magar and Tamang carrying the greatest proportions of Tibetan ancestry. We show that populations dwelling on the Himalayan plateau have had a clear impact on the Northern Indian gene pool. We illustrate how the Sherpa are a remarkably isolated population, with little gene flow from surrounding Nepalese populations. The online version of this article (doi:10.1186/s12864-016-3469-5) contains supplementary material, which is available to authorized users.