Evidence that very small embryonic-like stem cells are mobilized into peripheral blood
Evidence that very small embryonic-like stem cells are mobilized into peripheral blood
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DOI：
10.1634/stemcells.2007-0922
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发表时间：
2008-08-01
期刊：
影响因子：
5.2
通讯作者：
Ratajczak, Mariusz Z.
中科院分区：
文献类型：
--
作者：
Kucia, Magda J.;Wysoczynski, Marcin;Ratajczak, Mariusz Z.
最近，我们在小鼠成体组织（包括骨髓）中发现了一群非常小的胚胎样（VSEL）干细胞。在这里，我们提供了进一步的证据，证明这些细胞在稳定状态下以非常低的水平在外周血（PB）中循环（类似于100-200个细胞/ml），并且可以被额外动员（引诱药理学粒细胞集落刺激因子诱导或应激相关的动员），分别在注射四氯化碳或心脏毒素引起的毒性肝脏（或骨骼肌损伤）模型中得到证实。2月龄动物PB稳态循环VSEL干细胞数量比1月龄小鼠高5倍。总之，本研究支持了一个假设，即VSEL干细胞是一个可移动的原始干细胞池，可以从干细胞壁龛释放到PB中。然而，需要进一步的研究来确定这些细胞在PB中循环的水平是否可以成为评估成年生物体再生潜力和/或损伤临床结果的预后指标。
Recently, we identified in murine adult tissues, including bone marrow, a population of very small embryonic-like (VSEL) stem cells. Here, we provide further evidence that tinder steady-state conditions these cells circulate at very low levels in peripheral blood (PB) (similar to 100-200 cells/ml) and could be additionally mobilized (luring pharmacological granulocyte-colony-stimulating factor-induced or stress-related mobilization, as demonstrated in a model of toxic liver (or skeletal muscle damage induced by injection of carbon tetrachloride or cardiotoxin, respectively. The number of circulating VSEL stem cells under steady-state conditions in PB of 2-month-old animals was five times higher than that in 1-year-old mice. In conclusion, this study supports a hypothesis that VSEL stem cells are a mobile pool of primitive stem cells that could be released from the stem cell niches into PB. Further studies are needed, however, to see whether the level of these cells circulating in PB could become a prognostic indicator to assess the regenerative potential of an adult organism and/or clinical outcome from an injury.