Psychoneuroendocrine alterations during 5 days of head-down tilt bed rest and artificial gravity interventions
Psychoneuroendocrine alterations during 5 days of head-down tilt bed rest and artificial gravity interventions
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DOI：
10.1007/s00421-013-2640-9
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发表时间：
2013-08-01
影响因子：
3
通讯作者：
Feuerecker, M.
中科院分区：
文献类型：
--
作者：
Chouker, A.;Feuerecker, B.;Feuerecker, M.
本研究旨在探讨头低位卧床（HDTBR）5天（有或无人工重力（AG）影响）期间的心理应激和内分泌反应。参与者被分配到三个卧床协议之一，（i）无离心，（ii）连续30分钟（AG1）或（iii）不连续6 x 5分钟（AG2）离心周期，在质量中心周期为1G。每天进行一次检查。在HDTBR或离心之前、期间和之后，进行用于评估心理应激和相应生物样品收集的测试。总体而言，问卷调查显示，在HDTBR焦虑或情绪压力没有显着变化。在AG1组，唾液皮质醇水平显着较高离心后，无论HDTBR的进展和干预的日子。AG2组离心后皮质醇浓度仅在头低位倾斜的第一天升高，但在HDTBR的第5天不再升高。在卧床休息期间，所有组的尿肾上腺素排泄量均增加，但AG1组的日浓度最高，与AG2组相比也显著较高。这些结果表明，5天单独的HDT不是主要的应激源，因此随着时间的推移，仅导致神经内分泌反应的中度变化。然而，每天离心30分钟的连续持续时间诱导了显着的神经内分泌反应，这是不受习惯相比，每天但间歇离心6 × 5分钟。不连续离心是更好的耐受性，并与较低的肾上腺皮质应激反应在HDTBR。
This study aimed to investigate psychological stress and endocrine responses during 5 days of head-down tilt bed rest (HDTBR) with or without the impact of artificial gravity (AG). Participants were assigned to one of three bed-rest-protocols either with (i) no centrifugation, (ii) continuous 30 min (AG1) or (iii) discontinuous 6 x 5 min (AG2) centrifugation periods at 1G in the center of mass periods. Centrifugations were performed daily in one session. Questionnaires for assessing psychological stress and the corresponding biological sample collection were performed before, during and after HDTBR or centrifugation. Overall, questionnaires showed no significant changes of anxiety or emotional stress during HDTBR. In the AG1-group, salivary cortisol levels were significantly higher after centrifugation irrespective of the progress of the HDTBR and day of intervention. The AG2-group showed higher cortisol concentrations after centrifugation only on the first days of head-down tilt but no more on day 5 of HDTBR. During bed rest, urine epinephrine excretion increased in all groups, but showed the highest day concentrations in the AG1-group, which were also significantly higher when compared with AG2. These results indicate that 5 days of HDT alone is not a major stressor and accordingly resulted only in moderate changes of neuroendocrine responses over time. However, daily centrifugation for a continuous duration of 30 min induced a significant neuroendocrine response, which was not subject to a habituation as compared with daily but intermittent centrifugation for 6 x 5 min. Discontinuous centrifugation is better tolerated and associated with lower adrenocortical stress responses during HDTBR.