CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors.
CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors.
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发表时间：
2004
期刊：
影响因子：
56.9
通讯作者：
L. Madakamutil;U. Christen;C. Lena;Yiran Wang-Zhu;A. Attinger;M. Sundarrajan;W. Ellmeier;M. V. von Herrath;P. Jensen;D. Littman;H. Cheroutre
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文献类型：
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作者：
L. Madakamutil;U. Christen;C. Lena;Yiran Wang-Zhu;A. Attinger;M. Sundarrajan;W. Ellmeier;M. V. von Herrath;P. Jensen;D. Littman;H. Cheroutre
记忆T细胞是经历过抗原的长寿命T细胞，通常被认为是增殖的初级效应细胞的直系后代。然而，允许这些 T 细胞选择性存活的因素尚未明确。我们发现，在抗原刺激下，CD8 分子 (CD8αα) 的同二聚体 α 链在选定的 CD8αβ+ T 细胞亚群上短暂诱导。这些 CD8αα 分子促进活化淋巴细胞的存活和分化为记忆 CD8 T 细胞。因此，可以在初级效应细胞中鉴定记忆前体细胞，并通过 CD8αα 选择其生存和分化。
Memory T cells are long-lived antigen-experienced T cells that are generally accepted to be direct descendants of proliferating primary effector cells. However, the factors that permit selective survival of these T cells are not well established. We show that homodimeric alpha chains of the CD8 molecule (CD8alphaalpha) are transiently induced on a selected subset of CD8alphabeta+ T cells upon antigenic stimulation. These CD8alphaalpha molecules promote the survival and differentiation of activated lymphocytes into memory CD8 T cells. Thus, memory precursors can be identified among primary effector cells and are selected for survival and differentiation by CD8alphaalpha.