Chemoselective acylation of (hydroxyalkyl)phenols catalyzed by Candida antarctica lipase B
Chemoselective acylation of (hydroxyalkyl)phenols catalyzed by Candida antarctica lipase B
复制标题
南极假丝酵母脂肪酶 B 催化的（羟烷基）酚的化学选择性酰化
DOI：
10.1007/s10529-012-1124-z
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Hiroshi Danjo
中科院分区：
文献类型：
--
作者：
Toshifumi Miyazawa;Masato Yamamoto;Hiroshi Danjo
由Candida anastritica脂肪酶B催化的羟烷基酚与乙烯基酯的酰化反应以高度化学选择性的方式顺利进行，完全或至少主要得到它们的烷基酯。因此，该酶除了对有机合成具有通用催化能力之外，还能区分醇羟基和酚羟基。
Acylation of (hydroxyalkyl)phenols with vinyl esters by lipase B fromCandida antarcticaproceeded smoothly in a highly chemoselective manner, affording their alkyl esters exclusively or at least predominantly. The enzyme therefore discriminates between an alcoholic hydroxyl from a phenolic hydroxyl in addition to having versatile catalytic abilities for organic synthesis.