Generalized and Symptom-Specific Insight in Behavioral Variant Frontotemporal Dementia and Primary Progressive Aphasia
Generalized and Symptom-Specific Insight in Behavioral Variant Frontotemporal Dementia and Primary Progressive Aphasia
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DOI：
10.1176/appi.neuropsych.21.3.299
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发表时间：
2009-06-01
影响因子：
2.9
通讯作者：
Weintraub, Sandra
中科院分区：
文献类型：
--
作者：
Banks, Sarah Jane;Weintraub, Sandra
行为变异性额颞叶痴呆（FTD）和原发性进行性失语（PPA）是具有不同表现症状但随着进展症状重叠增加的相关痴呆。自知力丧失与早期行为变异FTD相关，但与PPA无关。本研究采用额面行为量表比较患者和护理人员的症状存在和严重程度的概念。发现行为变异型FTD患者的总体洞察力比PPA患者差。然而，PPA组对行为症状的洞察力降低，而行为变体FTD组对某些语言症状的洞察力完整。理论和临床意义进行了讨论。(The神经精神病学和临床神经科学杂志2009; 21：299-306）
Behavioral variant frontotemporal dementia (FTD) and primary progressive aphasia (PPA) are related dementias with different presenting symptoms but with increasing symptom overlap as they progress. Loss of insight is associated with early behavioral variant FTD, but not PPA. This study used the Frontal Behavioral Inventory to compare patient and caregiver concepts of symptom presence and severity. Patients with behavioral variant FTD were found to have worse insight overall than PPA patients. However, the PPA group showed reduced insight into behavioral symptoms, and the behavioral variant FTD groups had intact insight into some language symptoms. Theoretical and clinical implications are discussed. (The Journal of Neuropsychiatry and Clinical Neurosciences 2009; 21: 299-306)