Exosomes - vesicular carriers for intercellular communication
Exosomes - vesicular carriers for intercellular communication
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DOI：
10.1016/j.ceb.2009.03.007
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发表时间：
2009-08-01
影响因子：
7.5
通讯作者：
Raposo, Graca
中科院分区：
文献类型：
--
作者：
Simons, Mikael;Raposo, Graca
细胞释放不同类型的囊泡载体的膜和细胞质成分到细胞外空间。这些囊泡在内体系统内或在质膜上产生。在各种分泌膜囊泡中，外泌体是多泡内体与细胞表面融合后分泌的直径为40- 100nm的囊泡。外泌体不仅在不同细胞间传递膜组分，而且在细胞间传递核酸，强调其在细胞间通讯中的作用。这种能力可能是不同生理和病理事件的基础，其中涉及来自不同细胞起源的外泌体。直到最近，人们才对其生物发生和分泌的亚细胞区室和机制有所了解，为了解其功能开辟了新的途径。
Cells release different types of vesicular carriers of membrane and cytosolic components into the extracellular space. These vesicles are generated within the endosomal system or at the plasma membrane. Among the various kinds of secreted membrane vesicles, exosomes are vesicles with a diameter of 40-100 nm that are secreted upon fusion of multivesicular endosomes with the cell surface. Exosomes transfer not only membrane components but also nucleic acid between different cells, emphasizing their role in intercellular communication. This ability is likely to underlie the different physiological and pathological events, in which exosomes from different cell origins have been implicated. Only recently light have been shed on the subcellular compartments and mechanisms involved in their biogenesis and secretion opening new avenues to understand their functions.