Association of abdominal fat with metabolic syndrome components in overweight women: effect of menopausal status
Association of abdominal fat with metabolic syndrome components in overweight women: effect of menopausal status
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DOI：
10.1186/s40101-020-00222-0
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发表时间：
2020-04-19
影响因子：
3.1
通讯作者：
Tanaka, Kiyoji
中科院分区：
文献类型：
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作者：
Numao, Shigeharu;Katayama, Yasutomi;Tanaka, Kiyoji
背景 腹部脂肪分布与绝经状态代谢综合征 (MetSyn) 成分之间的关联尚未阐明。本研究的目的是检查绝经前和绝经后超重日本女性腹部脂肪室与 MetSyn 成分之间的横断面关联。方法 本研究对 212 名超重日本女性、76 名绝经前超重 (BMI >= 25) 女性（PreM 年龄，42.1 +/- 5.9 岁）和 87 名绝经后超重女性（PostM：年龄，56.2 +/- 4.5 岁）进行了分析。测量体重指数（BMI）、腹部间隔[内脏脂肪（VF）、皮下脂肪（SF）、浅层皮下脂肪（SSF）和深层皮下脂肪（DSF）]、血清高密度脂蛋白胆固醇（HDLC）、低密度脂蛋白胆固醇、甘油三酯（TG）和空腹血糖（FPG）。使用计算机断层扫描评估腹腔室。结果 PreM 和 PostM 之间的 BMI、SF、SSF 或 DSF 没有显着差异。尽管如此，PreM 的 VF 区域明显小于 PostM。然而，调整年龄后，VF 面积的差异消失了。 VFA 与 HDLC、TG 和 FPG 显着相关，与绝经状态无关。结论 这些结果表明，绝经状态对 VF 和 MetSyn 成分之间关联的影响可以忽略不计。无论绝经状态如何，超重女性的腹部皮下脂肪室与 MetSyn 成分均无关。
Background The association between abdominal fat distribution and metabolic syndrome (MetSyn) components by menopausal status has yet to be explicated. The purpose of this study was to examine a cross-sectional association between abdominal fat compartments and MetSyn components in pre- and post-menopausal overweight Japanese women. Methods Of 212 overweight Japanese women, 76 pre-menopausal overweight (BMI >= 25) women (PreM age, 42.1 +/- 5.9 years) and 87 post-menopausal overweight women (PostM: age, 56.2 +/- 4.5 years) were analyzed in this study. Measurements were taken for body mass index (BMI), abdominal compartments [visceral fat (VF), subcutaneous fat (SF), superficial subcutaneous fat (SSF), and deep subcutaneous fat (DSF)], serum high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol, triglycerides (TG), and fasting plasma glucose (FPG). Abdominal compartments were assessed using computed tomography. Results No significant differences were found for BMI, SF, SSF, or DSF between the PreM and PostM. Despite this, the PreM had a significantly smaller VF area than that of the PostM. However, the difference in VF area disappeared when age was adjusted for. VFA significantly correlated with HDLC, TG, and FPG independently of menopause status. Conclusions These results suggest that the effect of menopause status on the association between VF and MetSyn components is negligible. Abdominal subcutaneous fat compartments were not associated with MetSyn components in overweight women regardless of menopausal status.