Use of liquid ventilation with perflubron during extracorporeal membrane oxygenation: chest radiographic appearances.
Use of liquid ventilation with perflubron during extracorporeal membrane oxygenation: chest radiographic appearances.
复制标题
在体外膜肺氧合过程中使用 perflubron 进行液体通气：胸部放射学表现。
DOI：
10.1148/radiology.194.3.7862968
复制
发表时间：
1995
期刊：
影响因子：
19.7
通讯作者：
Shaffer,TH
中科院分区：
文献类型：
--
作者：
Gross,GW;Greenspan,JS;Fox,WW;Rubenstein,SD;Wolfson,MR;Shaffer,TH
目的探讨体外膜氧合(ECMO)治疗重症呼吸衰竭或肺动脉高压新生儿的疗效。材料和方法1例1个月大的婴儿和1例呼吸衰竭新生儿接受ECMO和全氟化钠液体通气，经气管插管缓慢滴入全氟化钠(40 m L，1 h以上；新生儿，1 h内注入28 m L)。结果1例婴儿在ECMO支持终止后存活，6个月后开始呼吸。结论少数有严重呼吸衰竭或肺动脉高压的新生儿或婴儿对ECMO治疗反应不佳，终止ECMO支持后死亡几乎是必然的。液体通气机和全氟化碳在这一患者群体中提供了一种潜在的抢救疗法。另外，全氟化钠是评价新生儿肺功能异常的良好造影剂。
PURPOSETo assess the effectiveness of performing liquid ventilation with perflubron in neonates with severe respiratory failure or pulmonary hypertension who receive extracorporeal membrane oxygenation (ECMO) life support.MATERIALS AND METHODSWe studied an infant (aged 1 month) and a neonate with respiratory failure who underwent ECMO and liquid ventilation with perflubron, which was slowly instilled via an endotracheal tube (in the infant, 40 mL for more than 1 hour; in the neonate, 28 mL within 1 hour).RESULTSThe infant survived termination of ECMO support and has been breathing room air since 6 months of age. The neonate died soon after ECMO support was withdrawn.CONCLUSIONA minority of neonates or infants with severe respiratory failure or pulmonary hypertension do not respond adequately to treatment with ECMO and are almost certain to die with termination of ECMO support. Liquid ventilation with perflubron offers a potential salvage therapy in this patient population. In addition, perflubron is a good contrast agent to use in the evaluation of neonatal pulmonary abnormalities.