Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations
Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations
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DOI：
10.1038/ijo.2011.86
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发表时间：
2012-01-01
影响因子：
4.9
通讯作者：
Tai, E-S
中科院分区：
文献类型：
--
作者：
Dorajoo, R.;Blakemore, A. I. F.;Tai, E-S
目的：最近的全基因组关联研究（GWAS）在欧洲人群中发现了38个肥胖相关基因座。然而，他们的肥胖在其他ethnics.Methods的贡献在很大程度上是未知的：我们利用5 GWAS（N = 10 482）从中国（三个队列，包括一个与2型糖尿病和另一个儿童），马来人和印度族裔群体从新加坡。数据集分别进行了分析，随后在合并荟萃分析中Z评分身体质量指数（BMI）association.Results：在FTO位点的变异显示最强的关联与BMI Z评分后荟萃分析（P值1.16 × 10（-7）- 7.95 × 10（-7））。我们进一步检测了与MC 4 R、GNPDA 2、TMEM 18、QTL/GIPR、BDNF、ETV 5、MAP 2K 5/SKOR 1、SEC 16 B和TNKS/MSRA基因座接近的其他9个指数肥胖变异的相关性（荟萃分析P值范围为3.58 x 10（-4）- 1.44 x 10（-2））。来自CADM 2、PTBP 2和FAIM 2的另外三个单核苷酸多态性（SNP）与BMI相关（P值
Objective: Recent genome-wide association studies (GWAS) have identified 38 obesity-associated loci among European populations. However, their contribution to obesity in other ethnicities is largely unknown.Methods: We utilised five GWAS (N = 10 482) from Chinese (three cohorts, including one with type 2 diabetes and another one of children), Malay and Indian ethnic groups from Singapore. Data sets were analysed individually and subsequently in combined meta-analysis for Z-score body-mass index (BMI) associations.Results: Variants at the FTO locus showed the strongest associations with BMI Z-score after meta-analysis (P-values 1.16 x 10(-7) - 7.95 x 10(-7)). We further detected associations with nine other index obesity variants close to the MC4R, GNPDA2, TMEM18, QPCTL/GIPR, BDNF, ETV5, MAP2K5/SKOR1, SEC16B and TNKS/MSRA loci (meta-analysis P-values ranging from 3.58 x 10(-4) - 1.44 x 10(-2)). Three other single-nucleotide polymorphisms (SNPs) from CADM2, PTBP2 and FAIM2 were associated with BMI (P-value