Versatile grafting of polysaccharides in homogeneous mild conditions by using atom transfer radical polymerization
Versatile grafting of polysaccharides in homogeneous mild conditions by using atom transfer radical polymerization
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DOI：
10.1021/bm0601373
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发表时间：
2006-07-10
影响因子：
6.2
通讯作者：
Crescenzi, Vittorio
中科院分区：
文献类型：
--
作者：
Bontempo, Debora;Masci, Giancarlo;Crescenzi, Vittorio
提出了一种不使用保护基化学，在均相温和条件下进行多糖接枝的原子转移自由基聚合（ATRP）方法。使用具有不同组成的水/DMF混合物作为溶剂。使用“接枝自”方法以制备具有良好控制的官能化程度的合适的支链淀粉和葡聚糖ATRP大分子引发剂。甲基丙烯酸酯和丙烯酰胺单体的接枝获得良好的控制的数量，分子量和多分散性的接枝链，而没有均聚物的形成和多糖降解。这种方法的多功能性使我们能够通过简单地改变溶剂组成和催化剂来制备具有广泛性质（两亲性、离子性和热响应性）的梳状衍生物。这使得从广泛的多糖开始合成新的有趣的生物材料成为可能。
A versatile atom transfer radical polymerization (ATRP) method for polysaccharide grafting in homogeneous mild conditions without using protecting group chemistry is presented. Water/DMF mixtures with different compositions were used as the solvent. The "grafting-from" approach was used in order to prepare suitable pullulan and dextran ATRP macroinitiators with a well controlled degree of functionalization. Methacrylate and acrylamide monomers were grafted obtaining good control over the number, molecular weight and polydispersity of the grafted chains without homopolymer formation and polysaccharide degradation. The versatility of this method allowed us to prepare comblike derivatives with a wide range of properties (amphiphilic, ionic, and ther-moresponsive) by simply changing the solvent composition and the catalyst. This could make possible the synthesis of new interesting biomaterials starting from a wide range of polysaccharides.