Neoantigens Generated by Individual Mutations and Their Role in Cancer Immunity and Immunotherapy.
Neoantigens Generated by Individual Mutations and Their Role in Cancer Immunity and Immunotherapy.
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DOI：
10.3389/fimmu.2017.01679
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发表时间：
2017
影响因子：
7.3
通讯作者：
Trajanoski Z
中科院分区：
文献类型：
--
作者：
Efremova M;Finotello F;Rieder D;Trajanoski Z
最近的临床前和临床研究已经证明了长期存在的假设，即肿瘤引起适应性免疫应答，并且驱动有效T细胞应答的抗原是新抗原，即，由体细胞突变基因产生的肽。因此，新抗原的表征和免疫原性抗原的鉴定对于改善癌症免疫疗法和将其功效扩大到更大比例的患者至关重要。在这篇综述中，我们首先介绍了使用下一代测序数据定量新抗原的方法，然后总结了使用这些工具表征实体癌中新抗原景观的结果。然后，我们讨论了使用检查点阻断剂，疫苗接种和过继性T细胞转移的癌症免疫治疗的新抗原的重要性。最后，我们概述了癌症免疫的新兴方面，包括肿瘤异质性和免疫编辑，并对未来前景进行了展望。
Recent preclinical and clinical studies have proved the long-standing hypothesis that tumors elicit adaptive immune responses and that the antigens driving effective T-cell response are neoantigens, i.e., peptides that are generated from somatically mutated genes. Hence, the characterization of neoantigens and the identification of the immunogenic ones are of utmost importance for improving cancer immunotherapy and broadening its efficacy to a larger fraction of patients. In this review, we first introduce the methods used for the quantification of neoantigens using next-generation sequencing data and then summarize results obtained using these tools to characterize the neoantigen landscape in solid cancers. We then discuss the importance of neoantigens for cancer immunotherapy using checkpoint blockers, vaccination, and adoptive T-cell transfer. Finally, we give an overview over emerging aspects in cancer immunity, including tumor heterogeneity and immunoediting, and give an outlook on future prospects.
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影响因子：
64.8
作者：
Matsushita, Hirokazu;Vesely, Matthew D.;Koboldt, Daniel C.;Rickert, Charles G.;Uppaluri, Ravindra;Magrini, Vincent J.;Arthur, Cora D.;White, J. Michael;Chen, Yee-Shiuan;Shea, Lauren K.;Hundal, Jasreet;Wendl, Michael C.;Demeter, Ryan;Wylie, Todd;Allison, James P.;Smyth, Mark J.;Old, Lloyd J.;Mardis, Elaine R.;Schreiber, Robert D.
通讯作者：
Schreiber, Robert D.
影响因子：
32.4
作者：
Abelin JG;Keskin DB;Sarkizova S;Hartigan CR;Zhang W;Sidney J;Stevens J;Lane W;Zhang GL;Eisenhaure TM;Clauser KR;Hacohen N;Rooney MS;Carr SA;Wu CJ
通讯作者：
Wu CJ
影响因子：
4
作者：
Jamal-Hanjani, Mariam;Thanopoulou, Eirini;Peggs, Karl S.;Quezada, Sergio A.;Swanton, Charles
通讯作者：
Swanton, Charles
影响因子：
64.5
作者：
Benci JL;Xu B;Qiu Y;Wu TJ;Dada H;Twyman-Saint Victor C;Cucolo L;Lee DSM;Pauken KE;Huang AC;Gangadhar TC;Amaravadi RK;Schuchter LM;Feldman MD;Ishwaran H;Vonderheide RH;Maity A;Wherry EJ;Minn AJ
通讯作者：
Minn AJ
影响因子：
11.2
作者：
Donia, Marco;Harbst, Katja;Svane, Inge Marie
通讯作者：
Svane, Inge Marie