Transcranial direct current stimulation reduces negative affect but not cigarette craving in overnight abstinent smokers.
Transcranial direct current stimulation reduces negative affect but not cigarette craving in overnight abstinent smokers.
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DOI：
10.3389/fpsyt.2013.00112
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发表时间：
2013
影响因子：
4.7
通讯作者：
Rahman AS
中科院分区：
文献类型：
--
作者：
Xu J;Fregni F;Brody AL;Rahman AS
经颅直流电刺激（tDCS）可以增强认知控制功能，包括健康和临床人群（包括早期戒烟（1.5小时）吸烟者）的注意力和对负面情绪和物质渴望的自上而下调节。本研究的目的是评估tDCS是否调节过夜戒烟烟草依赖吸烟者的负面影响，香烟渴望和注意力。在这项研究中，24名吸烟者在两个不同的日子在一夜戒烟后接受了真实的和假的tDCS治疗。在左侧背外侧前额叶皮层施加阳极，在右侧眶上区施加阴极，电流为2.0 mA，持续20 min。我们使用自我报告问卷的情绪状态（POMS），以评估负面影响和敦促吸烟（UTS）量表，以评估吸烟的渴望，和计算机视觉目标识别任务，以评估注意力之前和之后立即每个tDCS。吸烟者在接受真实的tDCS治疗后，总情绪障碍的POMS评分和紧张-焦虑、抑郁-沮丧和困惑-困惑子量表评分的降低幅度显著大于假tDCS治疗后。此外，这种负面影响的减少与Fagerström量表评估的尼古丁依赖水平呈正相关。然而，在真实的与假tDCS后，香烟渴望的减少没有差异，在视觉任务上的反应时间或命中率变化也没有差异。吸烟者没有报告tDCS的显著副作用。这项研究证明了tDCS的安全性及其在改善夜间戒烟吸烟者的负面影响方面的前景。其治疗烟草依赖的疗效值得进一步研究。
Transcranial direct current stimulation (tDCS) can enhance cognitive control functions including attention and top-down regulation over negative affect and substance craving in both healthy and clinical populations, including early abstinent (∼1.5 h) smokers. The aim of this study was to assess whether tDCS modulates negative affect, cigarette craving, and attention of overnight abstinent tobacco dependent smokers. In this study, 24 smokers received a real and a sham session of tDCS after overnight abstinence from smoking on two different days. We applied anode to the left dorsolateral prefrontal cortex and cathode to the right supra-orbital area for 20 min with a current of 2.0 mA. We used self-report questionnaires Profile of Mood States (POMS) to assess negative affect and Urge to Smoke (UTS) Scale to assess craving for cigarette smoking, and a computerized visual target identification task to assess attention immediately before and after each tDCS. Smokers reported significantly greater reductions in POMS scores of total mood disturbance and scores of tension–anxiety, depression–dejection, and confusion–bewilderment subscales after real relative to sham tDCS. Furthermore, this reduction in negative affect positively correlated with the level of nicotine dependence as assessed by Fagerström scale. However, reductions in cigarette craving after real vs. sham tDCS did not differ, nor were there differences in reaction time or hit rate change on the visual task. Smokers did not report significant side effects of tDCS. This study demonstrates the safety of tDCS and its promising effect in ameliorating negative affect in overnight abstinent smokers. Its efficacy in treating tobacco dependence deserves further investigation.