Inflammatory Biomarkers Differ among Hospitalized Veterans Infected with Alpha, Delta, and Omicron SARS-CoV-2 Variants.
Inflammatory Biomarkers Differ among Hospitalized Veterans Infected with Alpha, Delta, and Omicron SARS-CoV-2 Variants.
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DOI：
10.3390/ijerph20042987
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发表时间：
2023-02-08
影响因子：
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通讯作者：
Razjouyan J
中科院分区：
文献类型：
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作者：
Park C;Tavakoli-Tabasi S;Sharafkhaneh A;Seligman BJ;Hicken B;Amos CI;Chou A;Razjouyan J
COVID-19导致的死亡率与c反应蛋白（CRP）等实验室炎症标志物相关。组粒变异感染期间较低的死亡率可以用变异特异性免疫反应或宿主因素（如疫苗接种状况）来解释。我们假设，与α和δ相比，由Omicron变异引起的感染引起的炎症较少，与较低的死亡率相关。这是一项针对退伍军人健康管理局因COVID-19住院的退伍军人的回顾性队列研究。我们比较了欧米克隆感染住院患者的炎症标志物与α和δ的炎症标志物。我们报告了住院期间首次实验室结果和住院死亡率的调整优势比（aOR），按疫苗接种状况分层。在接受新冠肺炎检测的207.5564万名退伍军人中，符合标准的有29075人，分别是Alpha（45.1%）、Delta（23.9%）、Omicron（31.0%）。Delta组（aOR = 1.85, 95% CI: 1.64-2.09）和Alpha组（aOR = 1.94, 95% CI: 1.75-2.15） CRP异常的几率明显高于Omicron组。铁蛋白、丙氨酸转氨酶、天冬氨酸转氨酶、乳酸脱氢酶和白蛋白的变化趋势相同。Delta组（aOR = 1.92, 95% CI:1.73 ~ 2.12）和Alpha组（aOR = 1.68, 95% CI:1.47 ~ 1.91）的死亡率高于Omicron组。根据疫苗接种状况对结果进行分层后，结果仍然显著。感染欧米克隆的退伍军人表现出较轻的炎症反应和较低的死亡率。
Mortality due to COVID-19 has been correlated with laboratory markers of inflammation, such as C-reactive protein (CRP). The lower mortality during Omicron variant infections could be explained by variant-specific immune responses or host factors, such as vaccination status. We hypothesized that infections due to Omicron variant cause less inflammation compared to Alpha and Delta, correlating with lower mortality. This was a retrospective cohort study of veterans hospitalized for COVID-19 at the Veterans Health Administration. We compared inflammatory markers among patients hospitalized during Omicron infection with those of Alpha and Delta. We reported the adjusted odds ratio (aOR) of the first laboratory results during hospitalization and in-hospital mortality, stratified by vaccination status. Of 2,075,564 Veterans tested for COVID-19, 29,075 Veterans met the criteria: Alpha (45.1%), Delta (23.9%), Omicron (31.0%). Odds of abnormal CRP in Delta (aOR = 1.85, 95% CI:1.64–2.09) and Alpha (aOR = 1.94, 95% CI:1.75–2.15) were significantly higher compared to Omicron. The same trend was observed for Ferritin, Alanine aminotransferase, Aspartate aminotransferase, Lactate dehydrogenase, and Albumin. The mortality in Delta (aOR = 1.92, 95% CI:1.73–2.12) and Alpha (aOR = 1.68, 95% CI:1.47–1.91) were higher than Omicron. The results remained significant after stratifying the outcomes based on vaccination status. Veterans infected with Omicron showed milder inflammatory responses and lower mortality than other variants.