Nuclear magnetic resonance analysis of emulsified silicone oil RMN-3 (Oxane HD)
Nuclear magnetic resonance analysis of emulsified silicone oil RMN-3 (Oxane HD)
复制标题
乳化硅油 RMN-3 (Oxane HD) 的核磁共振分析
DOI：
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发表时间：
2007
影响因子：
4.1
通讯作者：
G. Kirkby
中科院分区：
文献类型：
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作者：
P. Tomlins;M. Woodcock;N. Spencer;G. Kirkby
背景资料：Oxane HD是5700 cs硅油和RMN-3（一种部分氟化烯烃）的混合物，其比重大于水，因此能够对下方视网膜裂孔进行眼内填塞。在2例接受Oxane HD治疗的复杂性视网膜脱离患者的前房中发现乳化油滴。分析从这两只眼睛中取出的样品，以研究乳化物质的性质。方法：将样品溶解在CDCl 3中，如有必要，使用硫酸镁干燥。使用核磁共振（NMR）将这些样品与未使用的市售产品进行比较。结果：从双眼眼前节取出的样品的NMR分析主要是硅油，只有微量的RMN-3。从未使用的Oxane HD注射器的不同区域采集的样品显示硅油中RMN-3化合物的浓度不同。结论：首先，RMN-3与硅油的混合物在体外和体内均不均匀。其次，前房中发现的乳化油几乎完全由硅油组成，仅含有微量的RMN-3。
Background: Oxane HD is a mixture of 5700 cs silicone oil and RMN-3 (a partly fluorinated olefin), which has a specific gravity greater than water, thereby enabling endotamponade of inferior retinal breaks. Droplets of emulsified oil were found in the anterior chamber of two patients with complex retinal detachments who had been treated with Oxane HD. Samples removed from these two eyes were analysed in order to investigate the nature of the emulsified substance. Methods: Samples were dissolved in CDCl3 and, if necessary, dried using magnesium sulphate. Nuclear magnetic resonance (NMR) was used to compare these samples with the unused commercial product. Results: NMR analysis of the samples removed from the anterior segment of both eyes were mainly silicone oil with only trace amounts of RMN-3. Samples taken from different areas of an unused syringe of Oxane HD demonstrated varying concentrations of the RMN-3 compound within the silicone oil. Conclusion: First, the mixture of RMN-3 and silicone oil is not homogenous either in vitro or in vivo. Second, emulsified oil found in the anterior chamber is composed almost entirely of silicone oil, containing only trace amounts of RMN-3.