Functional significance of synaptic terminal size in glutamatergic sensory pathways in thalamus and cortex.
Functional significance of synaptic terminal size in glutamatergic sensory pathways in thalamus and cortex.
复制标题
丘脑和皮质谷氨酸感觉通路中突触末端大小的功能意义。
DOI：
10.1113/jphysiol.2012.247619
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Sherman,SMurray
中科院分区：
文献类型：
--
作者：
Petrof,Iraklis;Sherman,SMurray
谷氨酸能通路是大脑中主要的信息携带和输入处理网络。有相当多的证据表明，多巴胺能通路并不代表一个同质的群体，它们可以分为至少两大类。1类突触能输入被认为是主要的信息载体，具有许多独特的突触和解剖学特征，例如它们经常终止的大突触终扣。另一方面，第2类输入，这被认为是发挥调节作用，相关联的，除其他功能外，专门小终端钮。在这里，我们总结并简要讨论这两类的神经元的输入，以及它们的独特功能，包括终端的终扣的大小和解剖结构，是如何与它们的建议功能。
Glutamatergic pathways are a major information‐carrying and ‐processing network of inputs in the brain. There is considerable evidence suggesting that glutamatergic pathways do not represent a homogeneous group and that they can be segregated into at least two broad categories. Class 1 glutamatergic inputs, which are suggested to be the main information carriers, are characterized by a number of unique synaptic and anatomical features, such as the large synaptic boutons with which they often terminate. On the other hand, Class 2 inputs, which are thought to play a modulatory role, are associated, amongst other features, with exclusively small terminal boutons. Here we summarize and briefly discuss these two classes of glutamatergic input and how their unique features, including their terminal bouton size and anatomy, are related to their suggested function.