Nuclear hormone receptors in podocytes.

Nuclear hormone receptors in podocytes.
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DOI:
10.1186/2045-3701-2-33
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发表时间:
2012-09-20
期刊:
影响因子:
7.5
通讯作者:
Kao HY
Kao HY
中科院分区:
生物学2区
文献类型:
--
作者:
Khurana S;Bruggeman LA;Kao HY

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核受体是一个配体激活的DNA序列特异性转录因子家族,其调节动物发育、细胞增殖、分化和稳态的各个方面。核受体及其配体在癌症和代谢综合征中的生理作用已被深入研究。然而,尽管它们的配体在临床上用于治疗肾脏疾病已有数十年,但它们在肾脏疾病中的作用仍在不断发展。本文就核受体及其配体在肾脏生理学中的作用及其在肾小球疾病和足细胞损伤修复反应中的作用进行综述。
Nuclear receptors are a family of ligand-activated, DNA sequence-specific transcription factors that regulate various aspects of animal development, cell proliferation, differentiation, and homeostasis. The physiological roles of nuclear receptors and their ligands have been intensively studied in cancer and metabolic syndrome. However, their role in kidney diseases is still evolving, despite their ligands being used clinically to treat renal diseases for decades. This review will discuss the progress of our understanding of the role of nuclear receptors and their ligands in kidney physiology with emphasis on their roles in treating glomerular disorders and podocyte injury repair responses.
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