Immune thrombocytopenic purpura in a child with thyroid hormone resistance – a rare presentation
Immune thrombocytopenic purpura in a child with thyroid hormone resistance – a rare presentation
复制标题
DOI：
10.1515/jpem-2012-0298
复制
发表时间：
2013-02
期刊：
影响因子：
--
通讯作者：
S. Sarkar;R. Mondal;M. Nandi;J. Ghosh
中科院分区：
文献类型：
--
作者：
S. Sarkar;R. Mondal;M. Nandi;J. Ghosh
摘要 甲状腺激素抵抗（RTH）是一种罕见的疾病，其特征是靶组织对甲状腺激素的反应性降低。尽管文献中报道了免疫性血小板减少性紫癜 (ITP) 与不同的甲状腺疾病相关，但其与 RTH 的共存情况尚不清楚。一名 9 岁女孩患有 ITP，并伴有甲状腺肿和生长迟缓等甲状腺功能减退症的症状。她随后被发现患有RTH。需要大剂量甲状腺激素替代来克服耐药性，这不仅可以改善甲状腺功能减退的特征，还可以使 ITP 明显缓解。
Abstract Resistance to thyroid hormone (RTH) is a rare entity characterized by a decreased target tissue responsiveness of thyroid hormones. Although immune thrombocytopenic purpura (ITP) has been reported with different thyroid disorders in the literature, its coexistence with RTH is not known. A 9-year-old girl presented with ITP and features of hypothyroidism in the form of goiter and growth retardation. She was subsequently found to have RTH. High-dose thyroid hormone replacement was required to overcome the resistance that not only ameliorated the features of hypothyroidism but also brought an apparent remission of ITP.