Discriminative and prognostic potential of cerebrospinal fluid phosphoTau/tau ratio and neurofilaments for frontotemporal dementia subtypes.
Discriminative and prognostic potential of cerebrospinal fluid phosphoTau/tau ratio and neurofilaments for frontotemporal dementia subtypes.
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DOI：
10.1016/j.dadm.2015.11.001
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发表时间：
2015-12-01
期刊：
影响因子：
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通讯作者：
Teunissen, Charlotte E
中科院分区：
文献类型：
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作者：
Pijnenburg, Yolande A L;Verwey, Nicolaas A;Teunissen, Charlotte E
简介：降低的脑脊液（CSF）p-Tau 181与总tau比值（p/t-tau）是额颞叶变性伴TDP 43包涵体（FTLD-TDP）和肌萎缩侧索硬化（ALS）的生物标志物。CSF轻链神经丝（NfL）在ALS中增加。方法：我们比较了FTLD-TDP伴ALS（n =15）、FTLD-TDP不伴ALS（n=17）、FTLD-Tau（n=6）、Alzheimer病（n=15）、Alzheimer病（n=17）和Alzheimer病（n=17）患者的CSF p/t-tau和NfL水平。（AD; n=25）和主观记忆投诉（SMC，n=24）。除FTLD-Tau外，所有组从伴ALS的FTLD-TDP到不伴ALS的FTLD-TDP到AD和SMC，p/t-tau比值均显著增加。伴ALS的FTLD-TDP中CSF NfL非常高，其次是不伴ALS、AD和SMC的FTLD-TDP。这两种生物标志物与survival.DISCUSSION相关：CSF p/t-tau比值和NfL水平强烈驱动ALS状态。因此，这些标志物似乎比诊断意义更具有预后意义。
INTRODUCTION: A decreased cerebrospinal fluid (CSF) p-Tau181 to total tau ratio (p/t-tau) is a biomarker for frontotemporal lobar degeneration with TDP43 inclusions (FTLD-TDP) and for amyotrophic lateral sclerosis (ALS). CSF light chain neurofilaments (NfL) are increased in ALS. We examined whether CSF p/t-tau and NfL are related to ALS status in FTLD-TDP.METHODS: We compared CSF p/t-tau and NfL levels between patients with FTLD-TDP with ALS (n=15), FTLD-TDP without ALS (n=17), FTLD-Tau (n=6), Alzheimer's disease (AD; n=25), and subjective memory complaints (SMC, n=24).RESULTS: Apart from FTLD-Tau, all groups differed significantly with increasing p/t-tau ratios from FTLD-TDP with ALS to FTLD-TDP without ALS to AD and SMC. CSF NfL was very high in FTLD-TDP with ALS followed by FTLD-TDP without ALS, AD, and SMC. Both biomarkers correlated with survival.DISCUSSION: CSF p/t-tau ratio and NfL levels are strongly driven by ALS status. These markers, therefore, appear to be more of prognostic than diagnostic significance.