Continued Incorporation of Circulating Radiolabeled Fibrinogen into Preformed Coronary Artery Thrombi
Continued Incorporation of Circulating Radiolabeled Fibrinogen into Preformed Coronary Artery Thrombi
复制标题
持续将循环放射性标记纤维蛋白原掺入预先形成的冠状动脉血栓中
作者：
A. Salimi;G. Oliver;J. Lee;L. Sherman
本研究通过放射性标记的纤维蛋白原摄取来测量实验性冠状动脉 (CA) 血栓随时间的增长情况。将125I-纤维蛋白原注射到狗体内，24小时后，电流诱导CA血栓。 CA血栓诱导后24小时，注射135I-白蛋白（A组）或131I-纤维蛋白原（B组）。血栓诱导后48小时，取出血栓，分成几段，并测量它们的放射性。 B 组血栓中的 131I-纤维蛋白原显着高于 A 组血栓中的 1311-白蛋白（P < 0.001）。在进一步的研究中，CA 血栓形成后 48 和 72 小时给予 131I-纤维蛋白原。在这些 CA 血栓中也发现了显着的 131I。 125I-纤维蛋白原和131I-纤维蛋白原掺入几乎发生在血栓的所有部分。结果表明：1) CA 血栓在初始形成后持续生长至少 72 小时； 2) 血栓中存在3l1l是由于纤维蛋白逐渐沉积在整个血栓中。
This study measured the growth over time of experimental coronary artery (CA) thrombi by radiolabeled fibrinogen uptake. 125I-fibrinogen was injected into dogs and 24 hours later CA thrombi were induced by electrical current. Twenty-four hours after CA thrombus induction, 135I-albumin (group A) or 131I-fibrinogen (group B) was injected. At 48 hours after thrombi induction, the thrombi were removed, divided into segments, and their radioactivity measured. The 131I-fibrinogen in the group B thrombi was significantly greater than the 1311-albumin in group A thrombi (P < 0.001). In further studies, the 131I-fibrinogen was given 48 and 72 hours post CA thrombus formation. Significant 131I was also found in these CA thrombi. 125I-fibrinogen and 131l-fibrinogen incorporation occurred in virtually all segments of the thrombi. The results suggest 1) CA thrombi growth continues for at least 72 hours after initial formation; 2) the presence of 3l1l in the thrombi was due to gradual fibnn deposition throughout the thrombus.