Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle age.
Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle age.
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DOI：
10.1016/j.metabol.2009.11.005
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发表时间：
2010-08
影响因子：
9.8
通讯作者：
Siscovick, David S.
中科院分区：
文献类型：
--
作者：
Fornage, Myriam;Papanicolaou, George;Lewis, Cora E.;Boerwinkle, Eric;Siscovick, David S.
胰岛素诱导基因2（INSIG 2）在胆固醇和脂肪酸合成的调节中起重要作用。一个多态性，rs7566605，位于10 kb的INSIG 2基因上游的肥胖的全基因组关联研究中确定。我们对12个INSIG 2 tagSNPs与纵向测量的体型（BMI和腰围）和脂质代谢（血浆HDL-，LDL-胆固醇和甘油三酯水平）进行了关联研究。我们在4,304名CARDIA参与者（49.5%黑人; 50.5%白人）中研究了他们与年龄的相互作用，前瞻性随访了20年。rs7566605与任何年龄的体型或脂质代谢变化无关，在任何种族组中。然而，rs 1352083和rs 10185316与白人中HDL-胆固醇的年龄相关性下降相关（分别为P=0.0005和0.04）。在研究期间一直保持BMI<25 kg/m2的黑人中观察到类似的趋势。这些数据支持INSIG 2序列变异在胆固醇代谢调节中的作用。
Insulin-induced gene 2 (INSIG2) plays an important role in the regulation of cholesterol and fatty acids synthesis. A polymorphism, rs7566605, located 10 kb upstream of the INSIG2 gene was identified in a genome-wide association study of obesity. We conducted an association study of 12 INSIG2 tagSNPs with longitudinal measures of body size (BMI and waist circumference) and lipid metabolism (plasma HDL-, LDL-cholesterol and triglycerides levels). We investigated their interaction with age in 4,304 CARDIA participants (49.5% Blacks; 50.5% Whites) followed prospectively for 20 years. rs7566605 was not associated with variation in body size or lipid metabolism at any age, in either racial group. However, rs1352083 and rs10185316 were associated with age-related decline in HDL-cholesterol in Whites (P=0.0005 and 0.04, respectively). A similar trend was observed in Blacks who consistently maintained a BMI<25 kg/m2 over the study period. These data support a role of INSIG2 sequence variation in the regulation of cholesterol metabolism.
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在研究中，在Indig2和PFKP中的常见变体与肥胖症中基于全基因组的相关性的不复制在18,014个DANES的研究中。
影响因子：
3.7
作者：
Andreasen CH;Mogensen MS;Borch-Johnsen K;Sandbaek A;Lauritzen T;Sørensen TI;Hansen L;Almind K;Jørgensen T;Pedersen O;Hansen T
通讯作者：
Hansen T
影响因子：
64.8
作者：
Frazer, Kelly A.;Ballinger, Dennis G.;Cox, David R.;Hinds, David A.;Stuve, Laura L.;Gibbs, Richard A.;Belmont, John W.;Boudreau, Andrew;Hardenbol, Paul;Leal, Suzanne M.;Pasternak, Shiran;Wheeler, David A.;Willis, Thomas D.;Yu, Fuli;Yang, Huanming;Zeng, Changqing;Gao, Yang;Hu, Haoran;Hu, Weitao;Li, Chaohua;Lin, Wei;Liu, Siqi;Pan, Hao;Tang, Xiaoli;Wang, Jian;Wang, Wei;Yu, Jun;Zhang, Bo;Zhang, Qingrun;Zhao, Hongbin;Zhao, Hui;Zhou, Jun;Gabriel, Stacey B.;Barry, Rachel;Blumenstiel, Brendan;Camargo, Amy;Defelice, Matthew;Faggart, Maura;Goyette, Mary;Gupta, Supriya;Moore, Jamie;Nguyen, Huy;Onofrio, Robert C.;Parkin, Melissa;Roy, Jessica;Stahl, Erich;Winchester, Ellen;Ziaugra, Liuda;Altshuler, David;Shen, Yan;Yao, Zhijian;Huang, Wei;Chu, Xun;He, Yungang;Jin, Li;Liu, Yangfan;Shen, Yayun;Sun, Weiwei;Wang, Haifeng;Wang, Yi;Wang, Ying;Xiong, Xiaoyan;Xu, Liang;Waye, Mary M. Y.;Tsui, Stephen K. W.;Wong, J. Tze-Fei;Galver, Luana M.;Fan, Jian-Bing;Gunderson, Kevin;Murray, Sarah S.;Oliphant, Arnold R.;Chee, Mark S.;Montpetit, Alexandre;Chagnon, Fanny;Ferretti, Vincent;Leboeuf, Martin;Olivier, Jean-Franccois;Phillips, Michael S.;Roumy, Stephanie;Sallee, Clementine;Verner, Andrei;Hudson, Thomas J.;Kwok, Pui-Yan;Cai, Dongmei;Koboldt, Daniel C.;Miller, Raymond D.;Pawlikowska, Ludmila;Taillon-Miller, Patricia;Xiao, Ming;Tsui, Lap-Chee;Mak, William;Song, You Qiang;Tam, Paul K. H.;Nakamura, Yusuke;Kawaguchi, Takahisa;Kitamoto, Takuya;Morizono, Takashi;Nagashima, Atsushi;Ohnishi, Yozo;Sekine, Akihiro;Tanaka, Toshihiro;Tsunoda, Tatsuhiko;Deloukas, Panos;Bird, Christine P.;Delgado, Marcos;Dermitzakis, Emmanouil T.;Gwilliam, Rhian;Hunt, Sarah;Morrison, Jonathan;Powell, Don;Stranger, Barbara E.;Whittaker, Pamela;Bentley, David R.;Daly, Mark J.;de Bakker, Paul I. W.;Barrett, Jeff;Chretien, Yves R.;Maller, Julian;McCarroll, Steve;Patterson, Nick;Pe'er, Itsik;Price, Alkes;Purcell, Shaun;Richter, Daniel J.;Sabeti, Pardis;Saxena, Richa;Schaffner, Stephen F.;Sham, Pak C.;Varilly, Patrick;Altshuler, David;Stein, Lincoln D.;Krishnan, Lalitha;Smith, Albert Vernon;Tello-Ruiz, Marcela K.;Thorisson, Gudmundur A.;Chakravarti, Aravinda;Chen, Peter E.;Cutler, David J.;Kashuk, Carl S.;Lin, Shin;Abecasis, Goncalo R.;Guan, Weihua;Li, Yun;Munro, Heather M.;Qin, Zhaohui Steve;Thomas, Daryl J.;McVean, Gilean;Auton, Adam;Bottolo, Leonardo;Cardin, Niall;Eyheramendy, Susana;Freeman, Colin;Marchini, Jonathan;Myers, Simon;Spencer, Chris;Stephens, Matthew;Donnelly, Peter;Cardon, Lon R.;Clarke, Geraldine;Evans, David M.;Morris, Andrew P.;Weir, Bruce S.;Tsunoda, Tatsuhiko;Johnson, Todd A.;Mullikin, James C.;Sherry, Stephen T.;Feolo, Michael;Skol, Andrew
通讯作者：
Skol, Andrew
影响因子：
30.8
作者：
de Bakker, PIW;Yelensky, R;Altshuler, D
通讯作者：
Altshuler, D
影响因子：
4.8
作者：
Sever, N;Song, BL;DeBose-Boyd, RA
通讯作者：
DeBose-Boyd, RA
影响因子：
16
作者：
Sever, N;Yang, T;DeBose-Boyd, RA
通讯作者：
DeBose-Boyd, RA