A Computational Model of the Functional Role of the Ventral-Striatal D2 Receptor in the Expression of Previously Acquired Behaviors
A Computational Model of the Functional Role of the Ventral-Striatal D2 Receptor in the Expression of Previously Acquired Behaviors
复制标题
腹侧纹状体 D2 受体在先前获得的行为表达中的功能作用的计算模型
作者：
A. Smith;S. Becker;S. Kapur
多巴胺的功能性作用吸引了大量的兴趣，因为它是经验发现，多巴胺阻断药物可用于治疗精神病。具体来说，D2受体及其在腹侧纹状体的表达已经成为我们理解精神分裂症，奖励和动机的神经调节剂的复杂作用的关键。我们离开无处不在的时间差（TD）模型的多巴胺神经元放电，使我们能够解释一系列的实验证据表明，腹侧纹状体多巴胺D2受体的操纵选择性地调节动机行为的远端与近端的结果。无论是内部模型还是TD方法（或两者的混合）更适合于全面阐述紧张性和阶段性多巴胺，都将对我们理解奖励、动机、精神分裂症和冲动性产生重要影响。我们还使用该模型来帮助将多巴胺功能的一些主要认知假设统一在计算的保护伞下。我们自己也用这个模型来激励和聚焦新一轮的实验研究。
The functional role of dopamine has attracted a great deal of interest ever since it was empirically discovered that dopamine-blocking drugs could be used to treat psychosis. Specifically, the D2 receptor and its expression in the ventral striatum have emerged as pivotal in our understanding of the complex role of the neuromodulator in schizophrenia, reward, and motivation. Our departure from the ubiquitous temporal difference (TD) model of dopamine neuron firing allows us to account for a range of experimental evidence suggesting that ventral striatal dopamine D2 receptor manipulation selectively modulates motivated behavior for distal versus proximal outcomes. Whether an internal model or the TD approach (or a mixture) is better suited to a comprehensive exposition of tonic and phasic dopamine will have important implications for our understanding of reward, motivation, schizophrenia, and impulsivity. We also use the model to help unite some of the leading cognitive hypotheses of dopamine function under a computational umbrella. We have used the model ourselves to stimulate and focus new rounds of experimental research.
影响因子：
1.9
作者：
K. Nader;Joseph E LeDoux
通讯作者：
K. Nader;Joseph E LeDoux