UTE-T2∗ mapping of human articular cartilage in vivo: a repeatability assessment.
UTE-T2∗ mapping of human articular cartilage in vivo: a repeatability assessment.
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UTE-T2™ 人体关节软骨体内图谱：重复性评估。
DOI：
10.1016/j.joca.2010.10.018
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发表时间：
2011
影响因子：
7
通讯作者：
Chu,CR
中科院分区：
文献类型：
--
作者：
Williams,A;Qian,Y;Chu,CR
关节软骨无回波时间增强T2序列(UTE-T2∗)成像是一种新的定量∗成像技术，能比标准T2序列成像更好地显示深层软骨的特征。在活体软骨的UTE-T2∗标测的可行性和节间重复性之前还没有被评估过。方法11名无症状的受试者在全身3T磁共振扫描仪上进行了连续三天的UTE-T2重复∗成像。对股骨内侧髁(CMFC)和胫骨平台(CMTP)中央负重区的全层、浅层和深层感兴趣区(ROI)进行了评价。每个ROI的UTE-T2∗值的均方根变异系数(RMSA-CV)和受试者内标准差的中位数来评估受试者间的精密度误差。结果体内UTE-T2 ROI的相对(RMSA-CV)误差分别为8%、6%和16%，绝对误差(SD)分别为1.2ms、1.5ms和1.5ms。结果体内UTE-T2 ROI的相对误差(RMSA-CV)分别为8%、6%和16%，绝对误差(SD)分别为1.2ms、1.5ms和1.5ms。在CMTP组织中，UTE-T2∗的相对重复性分别为8%、8%、13%，对应的绝对重复性为1.0ms、1.5ms、2.1ms(全层、浅层、深层)。在cMFC(P∗0.001)和CMTP(P=0.0004)区域，软骨浅层的UTE-T2值均高于深层(P=0.0004)。结论活体3T的3D UTE-T2∗定位是可行的，可以使用标准的临床≪扫描仪和膝关节线圈来实现。无症状受试者负重区UTE-T2RMSA-∗值的区间精度误差小于1.2ms或8%(RMSA-CV)。UTE-T2∗具有明显的地带性和区域性差异。
INTRODUCTIONUltrashort echo-time enhanced T2∗ (UTE-T2∗) mapping of articular cartilage is a novel quantitative MRI technique with the potential to visualize deep cartilage characteristics better than standard T2 mapping. The feasibility and intersession repeatability of UTE-T2∗ mapping of cartilage in vivo has not previously been evaluated.METHODSEleven asymptomatic subjects underwent repeat UTE-T2∗ imaging on a whole-body 3T MRI scanner on three consecutive days. Full-thickness, superficial and deep regions of interest (ROIs) were evaluated in the central weight-bearing zones of the medial femoral condyle (cMFC) and tibial plateau (cMTP). Intersession precision error across subjects was evaluated by the root-mean-square average coefficients of variation (RMSA-CV) and by the median of intra-subject standard deviations (SDs) of UTE-T2∗ values in each ROI.RESULTSUTE-T2∗ values in vivo were found to be repeatable with relative (RMSA-CV) intersession precision errors of 8%, 6%, 16% for full-thickness, superficial and deep cMFC ROIs, corresponding to absolute errors (SD) of 1.2, 1.5, 1.5ms, respectively. In cMTP tissue, UTE-T2∗ relative repeatability was 8%, 8%, 13%, corresponding to absolute repeatability of 1.0, 1.5, 2.1ms (full-thickness, superficial, deep). UTE-T2∗ values were higher in superficial cartilage compared to deep in both cMFC (P≪0.001) and cMTP (P=0.0004) regions.CONCLUSIONIn vivo 3D UTE-T2∗ mapping at 3T is feasible and can be implemented using a standard clinical MRI scanner and knee coil. Intersession precision error of UTE-T2∗ values in full-thickness ROIs in the weight-bearing regions of asymptomatic subjects is under 1.2ms or 8% (RMSA-CV). Significant zonal and regional variations of UTE-T2∗ were seen.