Acceleration of a Phosphate Diester Transesterification Reaction by Bis(alkylguanidinium) Receptors Containing an Appended General Base
Acceleration of a Phosphate Diester Transesterification Reaction by Bis(alkylguanidinium) Receptors Containing an Appended General Base
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DOI：
10.1002/anie.199512371
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发表时间：
1995-06
影响因子：
--
通讯作者：
V. Jubian;A. Veronese;R. P. Dixon;A. Hamilton
中科院分区：
文献类型：
--
作者：
V. Jubian;A. Veronese;R. P. Dixon;A. Hamilton
当添加带有碱性基团的双（胍）催化剂时，2-羟丙基-对硝基苯基磷酸酯的酯交换反应速率可提高高达 290 倍。附加碱基以及底物和受体的静电互补性的组合（参见复合物 1）使胍化合物成为有效的酶模拟物。这些类型的化合物可能具有作为人工核酸酶的治疗应用。（如图所示。）
Rate enhancements up to 290‐fold are possible for the transesterification of 2‐hydroxypropyl‐p‐nitrophenylphosphate when bis (guanidinium) catalysts bearing basic groups are added. The combination of the appended base and the electrostatic complementarity of substrate and receptor (see complex 1) make the guanidinium compounds efficient enzyme mimics. These types of compounds may have therapeutic applications as artificial nucleases.(Figure Presented.)