The Regulation of NF-κB Subunits by Phosphorylation.
The Regulation of NF-κB Subunits by Phosphorylation.
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DOI：
10.3390/cells5010012
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发表时间：
2016-03-18
期刊：
影响因子：
6
通讯作者：
Carmody RJ
中科院分区：
文献类型：
--
作者：
Christian F;Smith EL;Carmody RJ
NF-κB转录因子是炎症反应的主要调节因子，对免疫系统的稳态至关重要。NF-κB调节控制炎症、免疫细胞发育、细胞周期、增殖和细胞死亡的基因的转录。NF-κB在关键生理过程中发挥的基本作用使其成为决定健康和疾病的重要因素。NF-κB在组织稳态和免疫中的重要性使得旨在抑制NF-κB活化的治疗方法受挫。然而，大量的研究工作已经揭示了NF-κB磷酸化对控制NF-κB定向的反式激活的关键贡献。重要的是，NF-κB磷酸化以基因特异性方式控制转录，为选择性靶向NF-κB以获得治疗益处提供了新的机会。本文就NF-κB亚基的磷酸化及其对NF-κB功能的影响作一综述。
The NF-κB transcription factor is the master regulator of the inflammatory response and is essential for the homeostasis of the immune system. NF-κB regulates the transcription of genes that control inflammation, immune cell development, cell cycle, proliferation, and cell death. The fundamental role that NF-κB plays in key physiological processes makes it an important factor in determining health and disease. The importance of NF-κB in tissue homeostasis and immunity has frustrated therapeutic approaches aimed at inhibiting NF-κB activation. However, significant research efforts have revealed the crucial contribution of NF-κB phosphorylation to controlling NF-κB directed transactivation. Importantly, NF-κB phosphorylation controls transcription in a gene-specific manner, offering new opportunities to selectively target NF-κB for therapeutic benefit. This review will focus on the phosphorylation of the NF-κB subunits and the impact on NF-κB function.