EFFECTS OF LIPOPROTEINS ON PLASMA VISCOSITY
EFFECTS OF LIPOPROTEINS ON PLASMA VISCOSITY
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DOI：
10.1016/0021-9150(81)90107-6
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发表时间：
1981-01-01
期刊：
影响因子：
5.3
通讯作者：
SMITH, FR
中科院分区：
文献类型：
--
作者：
SEPLOWITZ, AH;CHIEN, S;SMITH, FR
高脂血症和混合性高脂血症患者血浆粘度显著高于对照组（P < 0.005）。70例高脂血症患者和对照组血浆粘度与血浆甘油三酯浓度呈显著正相关（r = 0.56，P < 0.01），与血浆胆固醇浓度呈轻度正相关（r = 0.29，P < 0.05）。当分离的脂蛋白组分以超过生理范围的浓度加入到无脂蛋白的血浆中时，血浆粘度与乳糜微粒浓度之间存在高度显著的线性关系（r = 0.98，P < 0.001）。当通过超离心去除乳糜微粒时，粘度恢复到基线水平。添加VLDL [极低密度脂蛋白]产生较小的影响（r = 0.70，P < 0.001），在研究的胆固醇浓度范围内，添加L[低]DL对粘度没有影响。乳糜微粒可增加血浆粘度。粘度增加的幅度证明可能反过来改变血流，并有助于症状，如间歇性跛行。乳糜微粒诱导的血浆粘度增加和随后的局部胰腺血流量减少可能是重度乳糜微粒血症和急性胰腺炎之间已知关系的一个因素。
Patients with hypertriglyceridemia and mixed hyperlipidemia have mean plasma viscosities significantly higher than controls (P < 0.005). In a group of 70 hyperlipidemic patients and controls, plasma viscosity was correlated with plasma triglyceride concentration (r = 0.56, P < 0.01) and to a lesser extent with the concentration of plasma cholesterol (r = 0.29, P < 0.05). When isolated lipoprotein fractions were added to lipoprotein-free plasma in increasing concentration over a physiological range, a highly significant linear relationship between plasma viscosity and chylomicron concentrations (r = 0.98, P < 0.001) was apparent. When chylomicrons were removed by ultracentrifugation, viscosity returned to baseline levels. Added VLDL [very low density lioprotein] produced a lesser effect (r = 0.70, P < 0.001) and added L[low]DL, over the range of cholesterol concentration studied, had no influence on viscosity. Chylomicrons can increase plasma viscosity. Viscosity increases of the magnitude demonstrated may in turn alter blood flow and contribute to symptoms such as intermittent claudication. Chylomicron-induced increases in plasma viscosity and subsequent decreases in local pancreatic blood flow may be a factor involved in the known relationship between severe chylomicronemia and acute pancreatitis.