Human serum albumin (HSA) coated liposomal indocyanine green for in vivo tumor imaging
Human serum albumin (HSA) coated liposomal indocyanine green for in vivo tumor imaging
复制标题
人血清白蛋白 (HSA) 包被的脂质体吲哚菁绿用于体内肿瘤成像
DOI：
10.1039/c5ra25129j
复制
发表时间：
2016-01-01
期刊：
影响因子：
3.9
通讯作者：
Chen, Yan
中科院分区：
文献类型：
--
作者：
Chen, Siqin;Yu, Gongjie;Chen, Yan
In this study, a near-infrared (NIR) fluorescent nanoprobe based on indocyanine green (ICG) was synthesized. In comparison with ICG solution, the resulting nanoprobe, namely HSA-lipid-ICG NPs, exhibited remarkable improvement in stability as well as higher NIR fluorescence intensity. The in vitro experimental results demonstrated that HSA-lipid-ICG NPs were nontoxic at physiologically relevant concentrations and could be efficiently uptaken by MCF-7 cells through endocytosis after 0.5 h incubation. The biodistribution of HSA-lipid-ICG NPs was evaluated in a mouse xenograft model. An optimized tumor contrast was observed after 8 h intravenous administration, while ICG solution had negligible effect. The tumor could be clearly detected and the signal lasted at least up to 24 h after injection. This nanoprobe may potentially serve as an ideal contrast agent for in vivo NIR fluorescence imaging.
