Accelerated immune senescence and HIV-1 infection
Accelerated immune senescence and HIV-1 infection
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DOI：
10.1016/j.exger.2006.12.003
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发表时间：
2007-05-01
影响因子：
3.9
通讯作者：
Papagno, Laura
中科院分区：
文献类型：
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作者：
Appay, Victor;Almeida, Jorge R.;Papagno, Laura
关于慢性免疫激活与HIV-1感染不良结局之间的关联，最近已达成共识。然而，其依据仍不清楚。越来越多的证据表明，免疫系统的细胞在体内可能具有有限的复制寿命。在这种情况下，慢性HIV感染期间持续激活可能导致免疫资源耗尽。这可能发生在两个层面：克隆和全球。一些HIV-1特异性CD 8 + T细胞在初次感染后不久就开始表达衰老标志物CD 57。持续活化的HIV-1特异性T细胞克隆可能最终达到复制衰老阶段并消失，导致对控制病毒复制重要的CD 8 + T细胞群体的特异性丧失。此外，HIV-1感染个体的特征在于高度分化的CD 8+和CD 4 + T细胞随时间的积累。随着T细胞更新能力的下降，这可能反映了淋巴细胞群体的普遍老化。在未感染HIV的老年人中也进行了类似的观察，这表明HIV-1感染中由于持续的免疫激活而发生过早的免疫衰老。(C)2007年爱思唯尔公司All rights reserved.
A recent consensus has emerged regarding the association between chronic immune activation and poor outcome in HIV-1 infection. However, its basis remains unclear. Accumulating evidence suggests that the cells of the immune system may have a limited replicative lifespan in vivo. In this context, persistent activation during chronic HIV infection may lead to an exhaustion of immune resources. This may occur at two levels: Clonal and Global. Some HIV-1-specific CD8+ T-cells start expressing the senescence marker CD57 soon after primary infection. Persistently activated HIV-1-specific T-cell clones may eventually reach stages of replicative senescence and disappear, resulting in the specific loss of CD8+ T-cell populations important to control viral replication. In addition, HIV-1 infected individuals are characterized by the accumulation of highly differentiated CD8+ and CD4+ T-cells overtime. Together with the decline of T-cell renewal capacities, this may reflect a general ageing of the lymphocyte population. Similar observations have been done in HIV non-infected elderly individuals, which suggests that premature immunosenescence occurs in HIV-1 infection, as a result of persistent immune activation. (C) 2007 Elsevier Inc. All rights reserved.