Labeled putrescine as a probe in brain tumors.
Labeled putrescine as a probe in brain tumors.
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标记腐胺作为脑肿瘤的探针。
DOI：
10.1126/science.6603020
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Brodie,JD
中科院分区：
文献类型：
--
作者：
Volkow,N;Goldman,SS;Flamm,ES;Cravioto,H;Wolf,AP;Brodie,JD
用放射性标记的腐胺作为恶性肿瘤的标记物来测定移植的 N-亚硝基甲基脲衍生的大鼠神经胶质瘤的多胺代谢。腐胺在体内的吸收在 5 分钟内完成，并且对肿瘤组织具有特异性。与邻近正常大脑的情况相反，肿瘤将腐胺转化为精胺和其他代谢物的速度很快。这些结果表明，碳11标记的腐胺可用作脑肿瘤选择性代谢成像的正电子发射断层扫描示踪剂，并且可在适当的模型中用作肿瘤生长速率的标记。
The polyamine metabolism of transplantedN-nitrosomethylurea-derived rat glioma was determined with radiolabeled putrescine used as a marker for malignancy. The uptake of putrescine in vivo was complete within 5 minutes and was specific for tumor tissue. The conversion of putrescine to spermine and other metabolites by the tumor was rapid, in contrast to the case for adjacent normal brain. These results suggest that putrescine labeled with carbon-11 may be used as a positron-emission tomographic tracer for the selective metabolic imaging of brain tumor and may be used in an appropriate model as a marker for tumor growth rate.