Analgesic Microneedle Patch for Neuropathic Pain Therapy.
Analgesic Microneedle Patch for Neuropathic Pain Therapy.
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DOI：
10.1021/acsnano.6b06104
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发表时间：
2017-01-24
期刊：
影响因子：
17.1
通讯作者：
Xie XS
中科院分区：
文献类型：
--
作者：
Xie X;Pascual C;Lieu C;Oh S;Wang J;Zou B;Xie J;Li Z;Xie J;Yeomans DC;Wu MX;Xie XS
由神经损伤引起的神经病理性疼痛使人虚弱且难以治疗。目前对神经病理性疼痛的全身药物治疗效果有限，且副作用不大，而目前的局部麻醉药往往非特异性地阻断感觉和运动功能。降钙素基因相关肽(CGRP)是一种由感觉神经末梢释放的神经肽，在慢性神经病理性疼痛中起重要作用。在这项研究中，研制了一种止痛微针(AMN)贴片，利用可溶微针无痛地经皮传递选择性CGRP拮抗肽，用于治疗局限性神经病理性疼痛。采用备用神经损伤和糖尿病神经病变痛等神经病理性疼痛模型和中波紫外线(UVB)诱导的神经源性炎性疼痛模型，通过测定大鼠对热刺激和机械刺激的行为痛敏感性来评价局部镇痛效果。与几种传统疗法不同，AMN贴片对神经病理性疼痛产生了有效的止痛，而不会干扰大鼠正常的伤害性感觉和运动功能，这是由于所传递的多肽对CGRP受体具有高度的特异性。AMN贴片没有引起皮肤刺激或全身副作用。这些结果表明，释放降钙素基因相关肽拮抗肽的可溶微针贴片提供了一种有效、安全和简单的方法来缓解神经病理性疼痛，具有明显的优势。
Neuropathic pain caused by nerve injury is debilitating and difficult to treat. Current systemic pharmacological therapeutics for neuropathic pain produce limited pain relief and have undesirable side effects, while current local anesthetics tend to nonspecifically block both sensory and motor functions. Calcitonin gene related peptide (CGRP), a neuropeptide released from sensory nerve endings, appears to play a significant role in chronic neuropathic pain. In this study, an analgesic microneedle (AMN) patch was developed using dissolvable microneedles to transdermally deliver selective CGRP antagonist peptide in a painless manner for the treatment of localized neuropathic pain. Local analgesic effects were evaluated in rats by testing behavioral pain sensitivity in response to thermal and mechanical stimuli using neuropathic pain models such as spared-nerve injury and diabetic neuropathy pain, as well as neurogenic inflammatory pain model induced by ultraviolet B (UVB) radiation. Unlike several conventional therapies, the AMN patches produced effective analgesia on neuropathic pain without disturbing the normal nociception and motor function of the rat, resulting from the high specificity of the delivered peptide against CGRP receptors. The AMN patches did not cause skin irritation or systemic side effects. These results demonstrate that dissolvable microneedle patches delivering CGRP antagonist peptide provide an effective, safe, and simple approach to mitigate neuropathic pain with significant advantages over current treatments.
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影响因子：
17.1
作者：
Chen, Mei-Chin;Lin, Zhi-Wei;Ling, Ming -Hung
通讯作者：
Ling, Ming -Hung
影响因子：
5.7
作者：
Abdi, S;Lee, DH;Chung, JM
通讯作者：
Chung, JM
影响因子：
7.4
作者：
ARNER, S;MEYERSON, BA
通讯作者：
MEYERSON, BA
影响因子：
5.7
作者：
Backonja, MM
通讯作者：
Backonja, MM
DOI：
10.1007/bf03016634
发表时间：
2007-12-01
期刊：
CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE
影响因子：
--
作者：
Irifune, Masahiro;Katayama, Sohtaro;Kawahara, Michio
通讯作者：
Kawahara, Michio