PRIMARY SENSORY NEUROPATHY WITH MUSCULAR CHANGES ASSOCIATED WITH CARCINOMA
PRIMARY SENSORY NEUROPATHY WITH MUSCULAR CHANGES ASSOCIATED WITH CARCINOMA
复制标题
DOI：
10.1136/jnnp.11.2.73
复制
发表时间：
1948-01-01
影响因子：
11
通讯作者：
DENNYBROWN, D
中科院分区：
文献类型：
--
作者：
DENNYBROWN, D
在多发性神经炎的许多临床形式中，仅影响感觉功能的一种非常不寻常，足以引起人们的注意。在较轻形式的感染性多发性神经炎和罕见的白喉后病例中，临床现象可能主要是感觉性的，但通常可以证明肌肉无力和消瘦的证据，特别是在近端肌群。所谓的糖尿病共济失调和酗酒也不是明显的感觉障碍。带状疱疹不仅局限于单个或相关的一组神经根，而且经常伴随着一种运动部件--前部脊髓灰质炎，如果受累的节段供应肢体的肌肉组织，这一点就更加明显。下面介绍的综合症可以归类为共济失调，因为它造成了严重的运动紊乱。从第一次全身感觉丧失的严重程度开始，从四肢周围开始，逐渐包括躯干，在一例中还包括面部，临床表现与背阔肌的区别。生前未怀疑“肌炎共存”。两名患者都是在1939年观察到的，虽然病理材料已被保存，但病例2的临床记录中有关患者疾病最后两个月的部分在战争年代期间被他入院的医院遗失；然而，从他早期疾病的个人记录中足以表明这两名患者的过程是相同的。
Among the many clinical forms of polyneuritis, one that affects sensory function alone is sufficiently unusual to attract more than passing attention. In milder forms of infective polyneuritis and in unusual post-diphtheritic cases the clinical phenomena may be predominantly sensory, but evidence of muscular weakness and wasting, particularly in proximal muscle groups, can usually be demonstrated. The so-called diabetic ataxia andalcoholic tabes are also not clear-cut sensory disorders. Herpetic zona is not only confined to a single or related group of nerve roots, but is also regularly accompanied by a motor component,-an anterior poliomyelitis, which is more evident if the involved segments supply the musculature of a limb. The syndrome presented below could be classed among the ataxias, pre-senting as it does a severe disorganization of movement. From the first the severity of loss of general sensation, beginning at the periphery of the limbs, advancing to include the trunk, and in one case the face, differentiated the clinical picture from that of tabes dorsalis. The coexistence of imyositis" was not suspected during life. Both patients* were observed in 1939, and though the pathological material has been pre7rved, the part of the clinical record of Case 2 dealIng1ith the last two months of the patient's illness was lost during the war years by the hospital where he was admitted; Sufficient, however, remains from rny personal record of the earlier part of his illness to indicate the identity of the process in the two patients.