Impact of cigarette smoking cessation on plasma α-klotho levels.
Impact of cigarette smoking cessation on plasma α-klotho levels.
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吸烟戒烟对等离子体α-klotho水平的影响。
DOI：
10.1097/md.0000000000011947
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发表时间：
2018-08
期刊：
影响因子：
1.6
通讯作者：
Miura SI
中科院分区：
文献类型：
--
作者：
Kamizono Y;Shiga Y;Suematsu Y;Imaizumi S;Tsukahara H;Noda K;Kuwano T;Fujimi K;Saku K;Miura SI
戒烟可以降低心血管疾病的风险，改善临床结果。我们研究了戒烟对血浆α-klotho水平的影响，α-klotho是一种抗衰老蛋白。作为为期12周的戒烟计划（VN-SEESAW研究）的一部分，我们用伐尼克兰（n= 14）或尼古丁透皮贴剂（n =14）治疗了28名吸烟者（男：女= 23：5，46 ± 12岁）。 分别于戒烟前后测定脉率、血压、血浆α-klotho、成纤维细胞生长因子（FGF）-19、FGF-21、血红蛋白（Hb）水平及呼气一氧化碳（CO）浓度。在所有受试者中，戒烟显著降低脉率、α-klotho、Hb和CO浓度，但不降低FGF-19或FGF-21。相反，干预后体重指数显著增加。α-klotho水平的变化（第12周的值-第0周的值）与第0周的α-klotho水平呈负相关，与Hb水平的变化呈正相关。此外，成功戒烟组（n = 21）显示脉率、收缩压、α-klotho、Hb和CO浓度显著降低。 总之，戒烟显著降低了抗衰老分子α-klotho的血清水平。我们的研究结果与先前的报告一致，即α-klotho的增加可能是对吸烟压力的补偿反应。
Smoking cessation reduces the risk of cardiovascular disease and improves clinical outcomes. We studied the effect of smoking cessation on plasma levels of α-klotho, which is an antiaging protein. We treated 28 smokers (male:female = 23:5, 46 ± 12 years) with varenicline (n = 14) or a transdermal nicotine patch (n = 14) as part of a 12-week smoking cessation program (the VN-SEESAW Study). Pulse rate, blood pressure, plasma levels of α-klotho, fibroblast growth factor (FGF)-19, FGF-21, hemoglobin (Hb), and expiratory carbon monoxide (CO) concentration were measured before and after the antismoking intervention. Smoking cessation significantly decreased pulse rate, α-klotho, Hb, and CO concentration, but not FGF-19 or FGF-21 in all subjects. On the contrary, body mass index significantly increased after the intervention. Changes in α-klotho levels (values at week 12 − values at week 0) were negatively associated with α-klotho levels at week 0 and positively associated with changes in Hb levels. In addition, the successful smoking cessation group (n = 21) showed significant reductions in pulse rate, systolic blood pressure, α-klotho, Hb, and CO concentration. In conclusion, smoking cessation significantly decreased serum levels of the antiaging molecule α-klotho. Our results are consistent with a previous report that an increase in α-klotho might be a compensatory response to smoking stress.