Does hygiene counseling have an impact on the rate of CMV primary infection during pregnancy? Results of a 3-year prospective study in a French hospital
Does hygiene counseling have an impact on the rate of CMV primary infection during pregnancy? Results of a 3-year prospective study in a French hospital
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DOI：
10.1016/j.jcv.2009.09.003
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发表时间：
2009-12-01
影响因子：
8.8
通讯作者：
Grangeot-Keros, Liliane
中科院分区：
文献类型：
--
作者：
Vauloup-Fellous, Christelle;Piconec, Olivier;Grangeot-Keros, Liliane
背景：巨细胞病毒(CMV)是发达国家最常见的先天性病毒感染原因。目的：本研究的目的是评估我国产前巨细胞病毒感染筛查和咨询政策的影响。研究设计：自2005年以来，我们产科中心的所有孕妇都被告知了CMV感染，如果她们同意，在妊娠12周左右进行血清学检测。如果第一次检测为阴性，则对妇女及其伴侣进行如何预防CMV感染的卫生咨询，并在36周左右进行第二次检测。结果：在5312名免疫状况不明或第一次来我中心进行CMV筛查时已知为阴性的妇女中，97.4%的人同意进行CMV筛查。在0~12wg之间发现11例原发感染(0.42%)，在12~36wg之间发现5例(0.19%)血清转换。结论：如果对孕期CMV感染有明确的信息，咨询后的血清转换率低于咨询前。(C)2009爱思唯尔B.V.保留所有权利。
Background: Cytomegalovirus (CMV) is the most frequent cause of congenital viral infection in developed countries.Objectives: The objective of this study was to evaluate the impact of our prenatal CMV infection screening and counseling policy.Study design: Since 2005, all pregnant women in our obstetric center have been informed about CMV infection, and if they agree, given a serological test at around 12 weeks of gestation (WG). If this first test is negative, the women and their partners are given hygiene counseling on how to prevent CMV infection, and a second test is performed at around 36 WG.Results: Among the 5312 women who had an unknown immune status, or were known to be seronegative when they had their first visit to our center for their current pregnancy, 97.4% agreed to CMV screening. Primary infection was detected in 11 women between 0 and 12 WG (0.42%), and seroconversion was diagnosed in five women between 12 and 36 WG (0.19%).Conclusions: These results suggest that if clear information is given on CMV infection during pregnancy, the rate of seroconversion is lower following counseling than before counseling. (c) 2009 Elsevier B.V. All rights reserved.