NERVE GROWTH FACTOR
NERVE GROWTH FACTOR
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DOI：
10.1111/j.1749-6632.1964.tb33978.x
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发表时间：
1964-01-01
影响因子：
5.2
通讯作者：
LEVIMONTALCINI, R
中科院分区：
文献类型：
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作者：
LEVIMONTALCINI, R
在过去的12年里，我们有幸两次向纽约科学院介绍我们在“神经生长因子”方面的工作。第一次是在1951年的秋天，当时我们报道了在小鼠肉瘤180和37中发现的可扩散的神经生长因子，它选择性地增强了鸡胚胎中交感神经节的生长和分化。第二次是在1959年秋天，当时我们报道了斯坦利·科恩和我在小鼠唾液腺中发现的一种有效的神经生长因子。我们还讨论了，在那个场合，唾液神经生长因子的特异性抗血清对新生哺乳动物交感神经节的影响。我们现在介绍我们最近对神经生长因子的某些方面的研究结果以及对免疫交感神经切除动物的药理学实验结果。然而，作为本届会议的第一次会议，我们认为，首先简要回顾一下过去几年中对现在被称为“神经生长因子”或更重要的“神经生长因子”这一引人注目的因子所做的大量工作可能是有益的。1918年，埃尔默·布克在《解剖学记录》上报告了他在鸡胚胎中进行的一项大胆而富有想象力的实验结果。实验包括将小鼠肉瘤180的片段植入三天鸡胚的体壁中。进行该实验是为了观察快速生长的组织（如这种类型的肉瘤）是否会为从相邻脊髓和感觉神经节出现的运动和感觉纤维提供合适的区域。移植的胚胎在五天后被处死。结果发现，感觉，但没有运动纤维分支到肿瘤，在同一时间的神经节提供的神经支配的肿瘤组织出现约33%比对侧神经节。作者得出结论，“肉瘤180移植物是腰骶神经节中观察到的肥大和增生的原因，这是由于内在的理化性质和生长机制。”我
Twice during the past 12 years we have had the privilege of presenting our work on the “nerve growth factor” to the New York Academy of Sciences. The first time was in the fall of 1951, when we reported on the discovery of a diffusible nerve growth factor in mouse sarcomas 180 and 37, which selectively enhances the growth and differentiation of the sympathetic ganglia in the chick embryo.’The second time was in the fall of 1959, when we reported on the diqcovery by Stanley Cohen and myself of a potent nerve growth factor in the mouse salivary glands. We also discussed, on that occasion, the effects of a specific antiserum to the salivary nerve growth factor on the sympathetic ganglia of newborn mammals.’We now present the results of our recent investigations on some aspects of the nerve growth factor as well as the results of pharmacological experiments on immunosympathectomized animals. As the first in this session, we feel however, that it may bs useful to give first a brief survey of the extensive work performe3 during these past years onthe remarkable agent which is now known as “the nerve growth factor”, or more si. mply as the NGF In 1918, Elmer Bueker reported in the Anatowical Records on the results of a bold and imaginative experiment he had performed in the chick embryo. The experiment consisted of the implantation of a fragment of mouse sarcoma 180 into the body wall of three-day chick embryos. The experiment was performed in order to see whether rapidly growing tissues such as this type of sarcoma would provide a suitable field for motor and sensory fibers emerging from the adjacent spinal cord and sensory ganglia. The embryos bearing the transplant were sacificed five days later. It was found that sensory, but no motor fibers had branched into the tumor and at the same time the ganlia providing for the innervation of the neoplastic tissue appeared about 33 per cent larger than contralateral ganglia. The author concluded that “sarcoma 180 transplants were responsible for the hypertrophy and hyperlasia observed in the lumbosacral ganglia because of intrinsic physjcochemical properties and mechanics of growth.” I